Neurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronil

dc.contributor.authorBarretto, M. L. M.
dc.contributor.authorHorta, D. F. [UNESP]
dc.contributor.authorAnselmo, F. [UNESP]
dc.contributor.authorGodinho, A. F. [UNESP]
dc.contributor.authorOliveira, A. A. F.
dc.contributor.institutionUniv Fed Rural Pernambuco
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T17:29:28Z
dc.date.available2020-12-10T17:29:28Z
dc.date.issued2020-01-01
dc.description.abstractFipronil is a selective-toxicity insecticide widely used in agriculture and veterinary medicine. However, there are reports of neurotoxic effects of this substance, causing damages to vertebrates. We evaluated the locomotor activity, motor coordination and the activity of brain acetylcholinesterase in rats exposed to fipronil. Adult male Wistar rats (n=15) received fipronil at a dose of 30mg/kg orally for 15 days; the Control group (n=15) was treated with oral solution in the same period. On the 16th day of experimentation, the animals were submitted to the open field arena test and hole-board test. On the 17th day, they were anesthetized and euthanized, and organs were collected, and subsequently brain AChE was evaluated. Exposure to fipronil yielded no significant changes on motor coordination and locomotor activity but caused significant inhibition of brain acetylcholinesterase activity. These findings suggest that fipronil may cause short-term neurotoxic effects, which may be exacerbated if exposure is prolonged.en
dc.description.affiliationUniv Fed Rural Pernambuco, Recife, PE, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Botucatu, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Botucatu, Botucatu, SP, Brazil
dc.format.extent169-176
dc.identifierhttp://dx.doi.org/10.1590/1678-4162-10738
dc.identifier.citationArquivo Brasileiro De Medicina Veterinaria E Zootecnia. Minas Gerais: Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 72, n. 1, p. 169-176, 2020.
dc.identifier.doi10.1590/1678-4162-10738
dc.identifier.fileS0102-09352020000100169.pdf
dc.identifier.issn0102-0935
dc.identifier.scieloS0102-09352020000100169
dc.identifier.urihttp://hdl.handle.net/11449/195283
dc.identifier.wosWOS:000523556000024
dc.language.isopor
dc.publisherArquivo Brasileiro Medicina Veterinaria Zootecnia
dc.relation.ispartofArquivo Brasileiro De Medicina Veterinaria E Zootecnia
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectpesticides
dc.subjectphenylpyralozes
dc.subjectneurotoxicity
dc.subjectopen field test
dc.subjecthole-board test
dc.titleNeurobehavioral assessment and brain acetylcholinesterase levels in rats subchronically exposed to fipronilen
dc.typeArtigo
dcterms.rightsHolderArquivo Brasileiro Medicina Veterinaria Zootecnia

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