The role of sex hormones and steroid receptors on female reproductive cancers

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dc.contributor.authorChuffa, Luiz Gustavo de Almeida [UNESP]
dc.contributor.authorLupi-Júnior, Luiz Antonio [UNESP]
dc.contributor.authorCosta, Aline Balandis
dc.contributor.authorAmorim, João Paulo de Arruda
dc.contributor.authorSeiva, Fábio Rodrigues Ferreira
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUENP/CLM – Universidade Estadual do Norte do Paraná
dc.contributor.institutionUNIOESTE/FB – Universidade Estadual do Oeste do Paraná
dc.date.accessioned2018-12-11T17:08:53Z
dc.date.available2018-12-11T17:08:53Z
dc.date.issued2017-01-01
dc.description.abstractSex steroids have been widely described to be associated with a number of human diseases, including hormone-dependent tumors. Several studies have been concerned about the factors regulating the availability of sex steroids and its importance in the pathophysiological aspects of the reproductive cancers in women. In premenopausal women, large fluctuations in the concentration of circulating estradiol (E2) and progesterone (P4) orchestrate many events across the menstrual cycle. After menopause, the levels of circulating E2 and P4 decline but remain at high concentration in the peripheral tissues. Notably, there is a strong relationship between circulating sex hormones and female reproductive cancers (e.g. ovarian, breast, and endometrial cancers). These hormones activate a number of specific signaling pathways after binding either to estrogen receptors (ERs), especially ERα, ERα36, and ERβ or progesterone receptors (PRs). Importantly, the course of the disease will depend on particular transactivation pathway. Identifying ER- or PR-positive tumors will benefit patients in terms of proper endocrine therapy. Based on hormonal responsiveness, effective prevention methods for ovarian, breast, and endometrial cancers represent a special opportunity for women at risk of malignancies. Hormone replacement therapy (HRT) might significantly increase the risk of these cancer types, and endocrine treatments targeting ER signaling may be helpful against E2-dependent tumors. This review will present the role of sex steroids and their receptors associated with the risk of developing female reproductive cancers, with emphasis on E2 levels in pre and postmenopausal women. In addition, new therapeutic strategies for improving the survival rate outcomes in women will be addressed.en
dc.description.affiliationDepartment of Anatomy IBB/UNESP Institute of Biosciences of Botucatu Univ. Estadual Paulista
dc.description.affiliationDepartment of Nursing UENP/CLM – Universidade Estadual do Norte do Paraná
dc.description.affiliationDepartment of Anatomy UNIOESTE/FB – Universidade Estadual do Oeste do Paraná
dc.description.affiliationDepartment of Biology and Technology UENP/CLM – Universidade Estadual do Norte do Paraná
dc.description.affiliationUnespDepartment of Anatomy IBB/UNESP Institute of Biosciences of Botucatu Univ. Estadual Paulista
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/02466-7
dc.description.sponsorshipIdFAPESP: 2016/03993-9
dc.format.extent93-108
dc.identifierhttp://dx.doi.org/10.1016/j.steroids.2016.12.011
dc.identifier.citationSteroids, v. 118, p. 93-108.
dc.identifier.doi10.1016/j.steroids.2016.12.011
dc.identifier.file2-s2.0-85008602468.pdf
dc.identifier.issn1878-5867
dc.identifier.issn0039-128X
dc.identifier.lattes5121319676503034
dc.identifier.scopus2-s2.0-85008602468
dc.identifier.urihttp://hdl.handle.net/11449/174044
dc.language.isoeng
dc.relation.ispartofSteroids
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBreast cancer
dc.subjectE2
dc.subjectEndometrial cancer
dc.subjectER
dc.subjectOvarian cancer
dc.subjectP4
dc.subjectPR
dc.titleThe role of sex hormones and steroid receptors on female reproductive cancersen
dc.typeResenha
unesp.author.lattes5121319676503034

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