NOVEL EVIDENCE THAT BETA-ADRENOCEPTORS OF THE MEDIAL SEPTAL AREA REGULATE BLOOD-PRESSURE AND ELECTROLYTE BALANCE

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dc.contributor.authorSaad, W. A.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorCamargo, LAA
dc.contributor.authorAntunesrodrigues, J.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:27:52Z
dc.date.available2014-05-20T15:27:52Z
dc.date.issued1995-09-15
dc.description.abstractWe investigated the participation of the beta-adrenoceptors of the septal area (SA) in sodium and potassium excretion and urine flow. The alterations in arterial pressure and some renal functions were also investigated. The injection of 2.10(-9) to 16.10(-9)M of isoproterenol, through a cannula permanently implanted into the SA produced a significant dose-dependent decrease in urinary Na+ and K+ excretion and urinary flow. Pretreatment with 16.10(-9) M butoxamine antagonized the effect of 4.10(-9) M isoproterenol but pretreatment with 16.10(-9) M practolol did not abolish the effect of isoproterenol. The beta 2-agonist terbutaline and salbutamol (4.10(-9) M when injected intraseptally also caused a decrease in urine flow and in renal Na+ and K+ excretion. After injection of isoproterenol or salbutamol (4.10(-9) M) into the SA, the arterial pressure, glomerular, filtration rate (GFR) and filtered Nd were reduced while Na+ fractional reabsorption was increased. The results indicate that the beta 2-adrenoceptors of the SA play a role in the decrease of Na+, K+ and urine flow and this effect may be due to a drop in GFR and filtered Na+ and to the rise in tubular Na+ reabsorption.en
dc.description.affiliationPAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST,BR-14801903 ARARAQUARA,SP,BRAZIL
dc.description.affiliationUnespPAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST,BR-14801903 ARARAQUARA,SP,BRAZIL
dc.format.extent1605-1611
dc.identifierhttp://dx.doi.org/10.1016/0024-3205(95)02136-7
dc.identifier.citationLife Sciences. Oxford: Pergamon-Elsevier B.V., v. 57, n. 17, p. 1605-1611, 1995.
dc.identifier.doi10.1016/0024-3205(95)02136-7
dc.identifier.issn0024-3205
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/37794
dc.identifier.wosWOS:A1995RV12800007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofLife Sciences
dc.relation.ispartofjcr3.234
dc.relation.ispartofsjr1,071
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSEPTAL AREApt
dc.subjectELECTROLYTE BALANCEpt
dc.subjectBLOOD PRESSUREpt
dc.titleNOVEL EVIDENCE THAT BETA-ADRENOCEPTORS OF THE MEDIAL SEPTAL AREA REGULATE BLOOD-PRESSURE AND ELECTROLYTE BALANCEen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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