Oxidative stress and sickle cell disease

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dc.contributor.authorDa Silva, Danilo Grünig Humberto [UNESP]
dc.contributor.authorJunior, Edis Belini [UNESP]
dc.contributor.authorBonini-Domingos, Claudia Regina [UNESP]
dc.contributor.authorDe Almeida, Eduardo Alves [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-30T11:13:05Z
dc.date.available2022-04-30T11:13:05Z
dc.date.issued2017-01-01
dc.description.abstractSickle cell disease (SCD) embraces a group of genetic hemolytic disorders associated with high morbidity and mortality. SCD is characterized by a complex pathophysiology initiated by hemoglobin S (HbS) polymerization that triggers a cascade of pathological events, including vaso-occlusion episodes, hemolysis, endothelial dysfunction, inflammation, hypercoagulability, reperfusion injury, and hypoxemia, leading to devastating clinical manifestations. Although SCD is one of the first disorders to be clearly defined at the molecular level, the genetic understanding of the basis for the disease expression variability is still not fully explained. In this intriguing scenario, oxidative stress plays a major role because it acts as both causing and being caused by SCD complications.en
dc.description.affiliationDepartment of Chemistry and Environmental Sciences Sao Paulo State University
dc.description.affiliationDepartment of Biology Sao Paulo State University
dc.description.affiliationUnespDepartment of Chemistry and Environmental Sciences Sao Paulo State University
dc.description.affiliationUnespDepartment of Biology Sao Paulo State University
dc.format.extent335-347
dc.identifierhttp://dx.doi.org/10.1201/b20228
dc.identifier.citationReactive Oxygen Species in Biology and Human Health, p. 335-347.
dc.identifier.doi10.1201/b20228
dc.identifier.scopus2-s2.0-85051955235
dc.identifier.urihttp://hdl.handle.net/11449/232785
dc.language.isoeng
dc.relation.ispartofReactive Oxygen Species in Biology and Human Health
dc.sourceScopus
dc.titleOxidative stress and sickle cell diseaseen
dc.typeCapítulo de livro

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