Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen

dc.contributor.authorVargas Estrada, Cristhian Rene [UNESP]
dc.contributor.authorFirmo, Bruna Fernanda [UNESP]
dc.contributor.authorBelchior Vela, Daniele [UNESP]
dc.contributor.authorMaronezi, Marjury Cristina [UNESP]
dc.contributor.authorRamirez Uscategui, Ricardo Andrés
dc.contributor.authorGasser, Beatriz [UNESP]
dc.contributor.authorRossi Feliciano, Marcus Antônio
dc.contributor.authorPavan, Letícia [UNESP]
dc.contributor.authorNogueira Aires, Luiz Paulo [UNESP]
dc.contributor.authorPiovan Lima, Gabriela [UNESP]
dc.contributor.authorDe Nardi, Andrigo Barboza [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Federal de Santa Maria
dc.date.accessioned2022-04-28T19:47:56Z
dc.date.available2022-04-28T19:47:56Z
dc.date.issued2021-12-01
dc.description.abstractThe aim of this study was to evaluate renal hemodynamics, routine clinical and laboratory parameters used to estimate renal function, and clinical evolution during six months in bitches with mammary carcinomas that underwent mastectomy and were treated (TG) or not (CG) with carprofen for three months after surgery. Twenty-six bitches with mammary carcinoma were equally distributed into TG that received carprofen 4.4 mg/kg/day for 90 days and CG that did not receive anti-inflammatory medication. Renal artery Doppler flowmetry, contrast-enhanced ultrasound (CEUS) of renal parenchyma, haematological, biochemical and clinical analyses were obtained once a month. These data were compared between groups and time via analysis of variance (ANOVA) in a completely randomized design with repeated measures (P < 0.05). On B-mode ultrasound, the area of the renal artery was greater (P = 0.0003) in the TG. Regarding laboratory findings, haematocrit and haemoglobin were similar in both groups, showing a significant and gradual increase after three months of treatment; MCV, MHC, and MCHC were increased (P < 0.05) and lymphocyte and band counts decreased (P < 0.05) in the TG. Regarding biochemical tests, ALT was the only parameter with a significant difference, being higher (P = 0.0272) in the treated group. It can be concluded that the use of carprofen for 90 days causes minimal changes in renal perfusion, erythrocyte parameters and ALT activity, and reduces the proportion of blood inflammatory cells. Therefore, use of this medication can be carried out safely in patients who require auxiliary cancer treatment.en
dc.description.affiliationFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista “Júlio de Mesquita Filho”–Jaboticabal
dc.description.affiliationUniversidade Federal dos Vales do Jequitinhonha e Mucuri–UFVJM
dc.description.affiliationUniversidade Federal de Santa Maria
dc.description.affiliationUnespFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista “Júlio de Mesquita Filho”–Jaboticabal
dc.identifierhttp://dx.doi.org/10.1038/s41598-021-02781-3
dc.identifier.citationScientific Reports, v. 11, n. 1, 2021.
dc.identifier.doi10.1038/s41598-021-02781-3
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85120736894
dc.identifier.urihttp://hdl.handle.net/11449/222999
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.sourceScopus
dc.titleUltrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofenen
dc.typeArtigo

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