Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds

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2018-08-01

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Coorientador

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Natural Products Inc

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Artigo

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Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8'R-7,8,7',8'-tetrahydro-8,8'-dimethyl-3,3'-dimethoxy-4,4'-dihydroxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 mu g/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 mu g/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5 mu g/mL.

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Inglês

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Natural Product Communications. Westerville: Natural Products Inc, v. 13, n. 8, p. 977-980, 2018.

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