Leaves of Eugenia brasiliensis Used as a Folk Medicine Contain Cyclooxygenase Enzyme and Lipid Peroxidation Inhibitory Compounds

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Dametto, Alessandra C. [UNESP]
Boralle, Nivaldo [UNESP]
Zhang, Chuan-Rui
Silva, Dulce H. S. [UNESP]
Nair, Muraleedharan G.
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Natural Products Inc
Tea prepared from leaves of Eugenia brasiliensis has been used as a folk medicine in Brazil to alleviate inflammation and pain. In this study, tea and methanolic extract inhibited cyclooxygenase (COX-1 and -2) enzymes and lipid peroxidation (LPO). Therefore, bioassay-guided purification of methanolic extract was carried out and afforded a new lignan (aR,8S,8'R-7,8,7',8'-tetrahydro-8,8'-dimethyl-3,3'-dimethoxy-4,4'-dihydroxy-dibenzocyclooctadiene) and three known C-methylated flavonoids (stropopinin; demethoxymatteucinol; myrigalone G). All isolates at 37.5 mu g/mL inhibited COX enzymes, similar to aspirin and ibuprofen used as controls at 108 and 12 mu g/mL, respectively. Most of the isolates also showed strong LPO inhibition at 5 mu g/mL.
Antioxidant, Cyclooxygenase, Cyclooctadiene lignan, C-Methylated flavonoid, Anti-inflammatory, Folk medicine
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Natural Product Communications. Westerville: Natural Products Inc, v. 13, n. 8, p. 977-980, 2018.