A new electrochemical platform based on low cost nanomaterials for sensitive detection of the amoxicillin antibiotic in different matrices

dc.contributor.authorWong, Ademar [UNESP]
dc.contributor.authorSantos, Anderson M.
dc.contributor.authorCincotto, Fernando H.
dc.contributor.authorMoraes, Fernando C.
dc.contributor.authorFatibello-Filho, Orlando
dc.contributor.authorSotomayor, Maria D.P.T. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionFederal University of Rio de Janeiro
dc.date.accessioned2020-12-12T01:39:10Z
dc.date.available2020-12-12T01:39:10Z
dc.date.issued2020-01-01
dc.description.abstractA new electrochemical device based on a combination of nanomaterials such as Printex 6L Carbon and cadmium telluride quantum dots within a poly(3,4-ethylenedioxythiophene) polystyrene sulfonate film was developed for sensitive determination of amoxicillin. The morphological, structural and electrochemical characteristics of the nanostructured material were evaluated using X-ray diffraction, confocal microscopy, transmission electron microscopy and voltammetric techniques. The synergy between these materials increased the electrochemical activity, the electron transfer rate and the electrode surface area, leading to a high magnitude of the anodic peak current for the determination of amoxicillin. The electrochemical determination of the antibiotic was carried out using square-wave voltammetry. Under the optimised experimental conditions, the proposed sensor showed high sensitivity, repeatability and stability to amoxicillin determination, with an analytical curve in the amoxicillin concentration range from 0.90 to 69 μmol L−1, and a low detection limit of 50 nmol L−1. No significant interference in the electrochemical signal of amoxicillin was observed from potential biological interferences and drugs widely used, such as uric acid, paracetamol, urea, ascorbic acid and caffeine. It was demonstrated that without any sample pre-treatment and using a simple measurement device, the sensor could be an alternative method for not only the analysis of pharmaceutical products (commercial tablets) and clinical samples (urine), but also to examine food quality (milk samples).en
dc.description.affiliationDepartment of Analytical Chemistry Institute of Chemistry State University of São Paulo (UNESP) and National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM)
dc.description.affiliationDepartment of Chemistry Federal University of São Carlos, P. O. Box 676
dc.description.affiliationInstitute of Chemistry Federal University of Rio de Janeiro
dc.description.affiliationUnespDepartment of Analytical Chemistry Institute of Chemistry State University of São Paulo (UNESP) and National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 160150/2015-9
dc.description.sponsorshipIdFAPESP: 2014/50945-4
dc.description.sponsorshipIdFAPESP: 2016/16565-5
dc.description.sponsorshipIdFAPESP: 2017/10118-0
dc.description.sponsorshipIdCNPq: 306650/2016-9
dc.description.sponsorshipIdCNPq: 405546/2018-1
dc.description.sponsorshipIdCNPq: 429462/2018-2
dc.identifierhttp://dx.doi.org/10.1016/j.talanta.2019.120252
dc.identifier.citationTalanta, v. 206.
dc.identifier.doi10.1016/j.talanta.2019.120252
dc.identifier.issn0039-9140
dc.identifier.scopus2-s2.0-85070791294
dc.identifier.urihttp://hdl.handle.net/11449/199415
dc.language.isoeng
dc.relation.ispartofTalanta
dc.sourceScopus
dc.subjectAmoxicillin
dc.subjectNew electrochemical sensor
dc.subjectPEDOT:PSS
dc.subjectPrintex 6L carbon
dc.subjectQuantum dots
dc.subjectReal samples
dc.titleA new electrochemical platform based on low cost nanomaterials for sensitive detection of the amoxicillin antibiotic in different matricesen
dc.typeArtigo

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