Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives

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Santos, Jean L. [UNESP]
Yamasaki, Paulo R. [UNESP]
Chin, Chung Man [UNESP]
Takashi, Celio H. [UNESP]
Pavan, Fernando Rogério [UNESP]
Leite, Clarice Queico Fujimura [UNESP]
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Pergamon-Elsevier B.V. Ltd
New phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 mu/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
Phthalimide derivatives, Antimycobacterial, Antitubercular activity, Cytotoxicity
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Bioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 17, n. 11, p. 3795-3799, 2009.