Oxidative Stress in Maternal Blood and Placenta From Mild Diabetic Rats

Nenhuma Miniatura disponível




Spada, Ana Paula Machado [UNESP]
Damasceno, Debora Cristina [UNESP]
Sinzato, Yuri Karen [UNESP]
Campos, Kleber Eduardo de [UNESP]
Faria, Priscila Afonso
Dallaqua, Bruna [UNESP]
Calderon, Iracema de Mattos Paranhos [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
Rodrigues, Tiago

Título da Revista

ISSN da Revista

Título de Volume


Sage Publications Inc


The aim of the present study was at evaluating the effects of oxidative stress in blood and placenta of mild diabetic Wistar rats. At birth, Wistar rats received citrate buffer (nondiabetic group, n = 15) and another group received streptozotocin (100 mg/kg, subcutaneous) to induce mild diabetes (diabetic, n = 15). The glycemia of these pregnant adult female rats were evaluated at days 0, 7, 14, and 21 of pregnancy, and at term pregnancy, the blood and placental samples were collected for oxidative stress measurements. The mild diabetes caused glycemia superior to 120 mg/dL during pregnancy, increased superoxide dismutase, glutathione peroxidase, glutathione reductase activities, and malondialdehyde levels in the blood, and catalase activity in the placenta. Thus, mild diabetes increased activities of antioxidant substances aiming at defending against the exacerbated oxidative stress but were not enough. The placenta also answered to diabetic milieu and increased antioxidant defense, showing that even a mild hyperglycemia was enough to cause placental and maternal blood changes.



streptozotocin, rats, diabetes, oxidative stress, placenta

Como citar

Reproductive Sciences. Thousand Oaks: Sage Publications Inc, v. 21, n. 8, p. 973-977, 2014.