Biocompatibility investigations of synthetic melanin and melanin analogue for application in bioelectronics

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Piacenti-Silva, Marina [UNESP]
Matos, Adriana Arruda
Paulin, João Vitor [UNESP]
Alavarce, Rafaela Alves da Silva
de Oliveira, Rodrigo Cardoso
Graeff, Carlos FO [UNESP]

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Biocompatibility tests were performed for melanin synthesized in water (W-Mel) and dimethylsulfoxide (D-Mel) aiming to evaluate its potential for bioelectronics application. In vitro biocompatibility of melanin was assessed using crystal violet assays with fibroblast cells (NIH3T3) cultured with W-Mel and D-Mel extracts in various dilutions. The results show that a high concentration of melanin kills the cells. However, after periods of 48 h incubation, cell viability is significantly favored after treatment with D-Mel at low concentrations (1:16, 1:32 and 1:64), as opposed to treatment with W-Mel extracts. Cellular adhesion tests show that fibroblast cells adhere to melanin thin films. These results show that D-Mel may be an interesting material for application in bioelectronic devices targeted for implants. © 2016 Society of Chemical Industry.



biocompatibility, bioelectronics, melanin, polymer

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Polymer International, v. 65, n. 11, p. 1347-1354, 2016.