Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride

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Chiba, Fernando Yamamoto [UNESP]
Colombo, Natalia Helena [UNESP]
Shirakashi, Daisy Jaqueline [UNESP]
de Souza Gomes, Wendrew Douglas [UNESP]
Moimaz, Suzely Adas Saliba [UNESP]
Garbin, Clea Adas Saliba [UNESP]
Silva, Cristina Antoniali [UNESP]
Sumida, Doris Hissako [UNESP]
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Int Soc Fluoride Research
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance.
Fluoride, Insulin receptor substrate, Insulin sensitivity, Insulin signal, Rats and insulin
Como citar
Fluoride. Ocean View: Int Soc Fluoride Research, v. 43, n. 1, p. 25-30, 2010.