Exercise training as treatment in cancer cachexia

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dc.contributor.authorLira, Fabio Santos [UNESP]
dc.contributor.authorRosa Neto, Jose Cesar
dc.contributor.authorSeelaender, Marilia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-12-03T13:11:39Z
dc.date.available2014-12-03T13:11:39Z
dc.date.issued2014-06-01
dc.description.abstractCachexia is a wasting syndrome that may accompany a plethora of diseases, including cancer, chronic obstructive pulmonary disease, aids, and rheumatoid arthritis. It is associated with central and systemic increases of pro-inflammatory factors, and with decreased quality of life, response to pharmacological treatment, and survival. At the moment, there is no single therapy able to reverse cachexia many symptoms, which include disruption of intermediary metabolism, endocrine dysfunction, compromised hypothalamic appetite control, and impaired immune function, among other. Growing evidence, nevertheless, shows that chronic exercise, employed as a tool to counteract systemic inflammation, may represent a low-cost, safe alternative for the prevention/ attenuation of cancer cachexia. Despite the well-documented capacity of chronic exercise to counteract sustained disease-related inflammation, few studies address the effect of exercise training in cancer cachexia. The aim of the present review was hence to discuss the results of cachexia treatment with endurance training. As opposed to resistance exercise, endurance exercise may be performed devoid of equipment, is well tolerated by patients, and an anti-inflammatory effect may be observed even at low-intensity. The decrease in inflammatory status induced by endurance protocols is paralleled by recovery of various metabolic pathways. The mechanisms underlying the response to the treatment are considered.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Biomed Sci, Immunometab Res Grp, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Canc Metab Res Grp, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Phys Educ, Immunometab Res Grp, Presidente Prudente, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 12/50079-0
dc.format.extent679-686
dc.identifierhttp://dx.doi.org/10.1139/apnm-2013-0554
dc.identifier.citationApplied Physiology Nutrition And Metabolism-physiologie Appliquee Nutrition Et Metabolisme. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 39, n. 6, p. 679-686, 2014.
dc.identifier.doi10.1139/apnm-2013-0554
dc.identifier.issn1715-5312
dc.identifier.urihttp://hdl.handle.net/11449/113377
dc.identifier.wosWOS:000337164600005
dc.language.isoeng
dc.publisherCanadian Science Publishing, Nrc Research Press
dc.relation.ispartofApplied Physiology Nutrition and Metabolism = Physiologie Appliquee Nutrition Et Metabolisme
dc.relation.ispartofjcr2.518
dc.relation.ispartofsjr1,112
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectexerciseen
dc.subjectcachexia-canceren
dc.subjectinflammationen
dc.subjectmetabolismen
dc.titleExercise training as treatment in cancer cachexiaen
dc.typeArtigo
dcterms.rightsHolderCanadian Science Publishing, Nrc Research Press
unesp.author.orcid0000-0001-7019-9762[2]
unesp.author.orcid0000-0002-9999-8020[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept
unesp.departmentEducação Física - FCTpt

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