Publicação:
Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay

dc.contributor.authorRibeiro, D. A.
dc.contributor.authorMarques, MEA
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:36:56Z
dc.date.available2014-05-20T13:36:56Z
dc.date.issued2005-10-01
dc.description.abstractDental bleaching is a simple and conservative procedure for aesthetic restoration of vital discoloured teeth. However, dental bleaching agents may represent a hazard to human health, especially by causing DNA strand breaks. Genotoxicity tests form an important part of cancer research and risk assessment of potential carcinogens. In the current study, the genotoxic potential associated with exposure to dental bleaching agents was assessed by the single cell gel (comet) assay in vitro. Six commercial dental bleaching agents (Clarigel Gold - Dentsply; Whitespeed - Discus Dental; Nite White - Discus Dental; Magic Bleaching - Vigodent; Whiteness HP - FGM and Lase Peroxide - DMC) were exposed to mouse lymphoma cells in vitro. The results pointed out that all dental bleaching agents tested contributed to the DNA damage as depicted by the mean tail moment. Clear concentration-related effects were obtained for DNA damaging, being the strongest effect observed at the highest dose of the hydrogen peroxide (Whiteness HP and Lase Peroxide, at 35% concentration). on the contrary, Whitespeed (Discus Dental) induced the lowest level of DNA breakage. Taken together, these results suggest that dental bleaching agents may be a factor that increases the level of DNA damage as detected by the single cell gel (comet) assay.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Patol,Botucatu Med Sch, Ctr Genotoxins & Carcinogens Evalut,TOXICAN, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Patol,Botucatu Med Sch, Ctr Genotoxins & Carcinogens Evalut,TOXICAN, BR-18618000 Botucatu, SP, Brazil
dc.format.extent766-771
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2842.2005.01500.x
dc.identifier.citationJournal of Oral Rehabilitation. Oxford: Blackwell Publishing, v. 32, n. 10, p. 766-771, 2005.
dc.identifier.doi10.1111/j.1365-2842.2005.01500.x
dc.identifier.issn0305-182X
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/12727
dc.identifier.wosWOS:000231825600011
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofJournal of Oral Rehabilitation
dc.relation.ispartofjcr2.051
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdental bleachingpt
dc.subjectmouse lymphoma cellspt
dc.subjectgenotoxicitypt
dc.subjectcomet assaypt
dc.titleAssessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assayen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
dspace.entity.typePublication
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.departmentPatologia - FMBpt

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