THE ESSENTIAL ROLE OF ZINC IN GROWTH

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dc.contributor.authorBrandaoneto, J.
dc.contributor.authorSTEFAN, V
dc.contributor.authorMendonca, B. B.
dc.contributor.authorBloise, W.
dc.contributor.authorCastro, AVB
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:29Z
dc.date.available2014-05-20T15:26:29Z
dc.date.issued1995-03-01
dc.description.abstractZinc is known to play a relevant role in growth and development. The basic mechanisms of action of this trace element are intimately linked to the structure and action of countless enzymes involved in many different metabolic processes. In this respect, when zinc specifically acts on cartilage growth it is involved in multiple enzymatic reactions which make this a multifactorial event. Thus, we may divide the actions of zinc into three distinct types: 1) action on taste and smell acuity, appetite regulation, and food consumption and regulation; 2) action on DNA and RNA synthesis stimulating a) cell replication and differentiation of chondrocytes, osteoblasts and fibroblasts; b) cell transcription culminating in the synthesis of somatomedin-C (liver), alkaline phosphatase, collagen and osteocalcin (bone), and c) protein, carbohydrate and lipid metabolism, that is intimately related to the mechanisms of smell, taste, appetite, and food consumption and utilization; 3) action on hormonal mediation by participating in a) GH synthesis and secretion in somatomammotroph cells, b) the action of GH on liver somatomedin-C production, and c) somatomedin-C activation in bone cartilage. In addition to these multiple functions, zinc also interacts with other hormones somehow related to bone growth such as testosterone, thyroid hormones, insulin, and vitamin D-3.On the basis of the above considerations, we conclude that the integration of these mechanisms contributes to the perfect physiological functioning of bone. Tn the presence of zinc deficiency, this homeostasis is impaired, causing the weight-height deficiency detected in several species studied, the human species in particular.en
dc.description.affiliationUNIV SAO PAULO,DEPT MED,DIV ENDOCRINOL,BR-05340901 SAO PAULO,BRAZIL
dc.format.extent335-358
dc.identifierhttp://dx.doi.org/10.1016/0271-5317(95)00003-8
dc.identifier.citationNutrition Research. Oxford: Pergamon-Elsevier B.V., v. 15, n. 3, p. 335-358, 1995.
dc.identifier.doi10.1016/0271-5317(95)00003-8
dc.identifier.issn0271-5317
dc.identifier.urihttp://hdl.handle.net/11449/36645
dc.identifier.wosWOS:A1995QJ51400003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNutrition Research
dc.relation.ispartofjcr2.707
dc.relation.ispartofsjr1,135
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectZINCpt
dc.subjectGROWTHpt
dc.subjectENZYMATIC MECHANISMSpt
dc.subjectBONE METABOLISMpt
dc.subjectHORMONAL MEDIATIONpt
dc.titleTHE ESSENTIAL ROLE OF ZINC IN GROWTHen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0003-1762-1084[3]

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