Liberação de óxido nítrico e tnf-α em macrófagos peritoneais na presença de Melampodium divaricatum (Asteraceae)
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Data
2001-12-01
Autores
Moreira, Raquel Regina Duarte [UNESP]
Tiossi, Lenon César Lucas [UNESP]
Furukava, Cristiane Rumi [UNESP]
Maia, Danielle Cardoso Geraldo [UNESP]
Santos, Luis Eduardo dos [UNESP]
Placeres, Marisa Campos Polesi [UNESP]
Carlos, Iracilda Zeppone [UNESP]
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Resumo
The immune responses are mediated by a variety cells and molecules that cells secreted. Macrophages are the first cells that participate in the immune response, and, when are activated, release more than hundred compounds at the extracelular medium, such as cytokine (TNF-α) and the intermediate compounds of the nitrogen (NO). In this paper the release of nitric oxide (NO) and necrose tumoral factor (TNF-α) were determined in peritoneal macrophage cultures of mice in the presence of the 70% ethanolic extract obtained from the flowers of the Melampodium divaricatum (Asteraceae) in the concentrations of 20, 10 and 5 mg/mL. The 70% ethanolic extracts from flowers of the Melampodium divaricatum presented higher liberation of NO and TNF-α in the concentration of the 20 mg/mL when compared with LPS. We conclude that this extract is a potente stimulator of macrophage, could be immunomodulatory activity.
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Palavras-chave
Extract, Macrophage, Melampodium divaricatum, Nitric oxide, Tumor necrosis factor-α, lipopolysaccharide, nitric oxide, plant extract, tumor necrosis factor alpha, animal cell, Asteraceae, concentration response, controlled study, drug effect, drug isolation, drug synthesis, enzyme release, female, flower, immune response, immunoreactivity, mouse, nonhuman, peritoneum macrophage
Como citar
Revista de Ciencias Farmaceuticas, v. 22, n. 2, p. 251-261, 2001.