Scavenging activity on reactive oxygen species with biological relevance by the Brazilian non-conventional spice Varronia curassavica
dc.contributor.author | Veloso, Gabriela Brasil Romão | |
dc.contributor.author | Assis, Renata Pires | |
dc.contributor.author | Pereira, Juhan Augusto Scardelato | |
dc.contributor.author | Soares, Christiane Pienna | |
dc.contributor.author | Brunetti, Iguatemy Lourenço | |
dc.contributor.author | Isaac, Vera Lucia Borges | |
dc.contributor.author | Ricelli, Paulo | |
dc.contributor.author | Zocolo, Guilherme | |
dc.contributor.author | Corrêa, Marcos Antonio | |
dc.contributor.author | Santos, André Gonzaga dos | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2022-01-20T17:29:02Z | |
dc.date.available | 2022-01-20T17:29:02Z | |
dc.date.issued | 2022-01-18 | |
dc.description.abstract | Varronia curassavica Jacq. is a Non-Conventional Edible Plant (spice) commonly found in Brazil used in folk medicine as anti-inflammatory. The present study aimed to investigate the in vitro antioxidant activity of the hydroethanolic extract of V. curassavica leaves (EtEVc) on reactive oxygen species with biological importance. The tests performed include O2•-, ROO•, HOCl/OCl-, H2O2 and ABTS•+/DPPH• capture. The putative identification of the major compounds was performed by UPLC-ESIQToF- MSE and in vitro cytotoxicity was evaluated. The antioxidant activity of EtEVc was very promising in all tests, highlighting on the capture of O2•-, which the EC50 value was three times lower than Trolox (EtEVc EC50 = 197 μg/mL and Trolox EC50 = 591 μg/mL); and it could be due to the presence of the major compounds, rosmarinic acid, salvianolic acid and quercetin derivates. EtEVc also presented low cytotoxicity. Thus, EtEVc has great potential for use as antioxidant agent. | pt |
dc.description.affiliation | São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, Brazil | |
dc.description.affiliation | São Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil | |
dc.description.affiliation | Embrapa Agroindústria Tropical, Empresa Brasileira de Pesquisa Agropecuária (Embrapa), Rua Dr. Sara Mesquita nº 2270, 60511-110, Fortaleza, Ceará, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.identifier.orcid | 0000-0001-8984-2869 | |
dc.identifier.orcid | 0000-0003-1070-9569 | |
dc.identifier.orcid | 0000-0003-1740-7360 | |
dc.identifier.orcid | 0000-0003-4927-7599 | |
dc.identifier.orcid | 0000-0001-7402-920X | |
dc.identifier.orcid | 0000-0002-5258-4015 | |
dc.identifier.orcid | 0000-0001-8835-0184 | |
dc.identifier.orcid | 0000-0001-9229-3039 | |
dc.identifier.orcid | 0000-0002-4920-2506 | |
dc.identifier.uri | http://hdl.handle.net/11449/215984 | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Food Chemistry | pt |
dc.rights.accessRights | Acesso restrito | |
dc.subject | Varronia curassavica extract | pt |
dc.subject | Non-Conventional Edible Plant (PANC) | pt |
dc.subject | Antioxidant activity | pt |
dc.subject | Reactive oxygen species (ROS) | pt |
dc.subject | Oxidative stress | pt |
dc.title | Scavenging activity on reactive oxygen species with biological relevance by the Brazilian non-conventional spice Varronia curassavica | pt |
dc.type | Artigo | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Fármacos e Medicamentos - FCF | pt |
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