Scavenging activity on reactive oxygen species with biological relevance by the Brazilian non-conventional spice Varronia curassavica

dc.contributor.authorVeloso, Gabriela Brasil Romão
dc.contributor.authorAssis, Renata Pires
dc.contributor.authorPereira, Juhan Augusto Scardelato
dc.contributor.authorSoares, Christiane Pienna
dc.contributor.authorBrunetti, Iguatemy Lourenço
dc.contributor.authorIsaac, Vera Lucia Borges
dc.contributor.authorRicelli, Paulo
dc.contributor.authorZocolo, Guilherme
dc.contributor.authorCorrêa, Marcos Antonio
dc.contributor.authorSantos, André Gonzaga dos
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2022-01-20T17:29:02Z
dc.date.available2022-01-20T17:29:02Z
dc.date.issued2022-01-18
dc.description.abstractVarronia curassavica Jacq. is a Non-Conventional Edible Plant (spice) commonly found in Brazil used in folk medicine as anti-inflammatory. The present study aimed to investigate the in vitro antioxidant activity of the hydroethanolic extract of V. curassavica leaves (EtEVc) on reactive oxygen species with biological importance. The tests performed include O2•-, ROO•, HOCl/OCl-, H2O2 and ABTS•+/DPPH• capture. The putative identification of the major compounds was performed by UPLC-ESIQToF- MSE and in vitro cytotoxicity was evaluated. The antioxidant activity of EtEVc was very promising in all tests, highlighting on the capture of O2•-, which the EC50 value was three times lower than Trolox (EtEVc EC50 = 197 μg/mL and Trolox EC50 = 591 μg/mL); and it could be due to the presence of the major compounds, rosmarinic acid, salvianolic acid and quercetin derivates. EtEVc also presented low cytotoxicity. Thus, EtEVc has great potential for use as antioxidant agent.pt
dc.description.affiliationSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Araraquara, São Paulo, Brazil
dc.description.affiliationSão Paulo State University (Unesp), School of Pharmaceutical Sciences, Department of Clinical Analysis, Araraquara, São Paulo, Brazil
dc.description.affiliationEmbrapa Agroindústria Tropical, Empresa Brasileira de Pesquisa Agropecuária (Embrapa), Rua Dr. Sara Mesquita nº 2270, 60511-110, Fortaleza, Ceará, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.identifier.orcid0000-0001-8984-2869
dc.identifier.orcid0000-0003-1070-9569
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.orcid0000-0003-4927-7599
dc.identifier.orcid0000-0001-7402-920X
dc.identifier.orcid0000-0002-5258-4015
dc.identifier.orcid0000-0001-8835-0184
dc.identifier.orcid0000-0001-9229-3039
dc.identifier.orcid0000-0002-4920-2506
dc.identifier.urihttp://hdl.handle.net/11449/215984
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofFood Chemistrypt
dc.rights.accessRightsAcesso restrito
dc.subjectVarronia curassavica extractpt
dc.subjectNon-Conventional Edible Plant (PANC)pt
dc.subjectAntioxidant activitypt
dc.subjectReactive oxygen species (ROS)pt
dc.subjectOxidative stresspt
dc.titleScavenging activity on reactive oxygen species with biological relevance by the Brazilian non-conventional spice Varronia curassavicapt
dc.typeArtigo
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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