Dietary supplementation with multi-strain formula of probiotics modulates inflammatory and immunological markers in apical periodontitis

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dc.contributor.authorCosme-Silva, Leopoldo
dc.contributor.authorDal Fabbro, Renan [UNESP]
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorDo Prado, Alana Sant’Ana [UNESP]
dc.contributor.authorde Oliveira, Daniel Pinto
dc.contributor.authorde Marcelos, Priscylla Gonçalves Correia Leite
dc.contributor.authorGomes-Filho, João Eduardo [UNESP]
dc.contributor.institutionFaculdade de Odontologia
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T10:51:58Z
dc.date.available2021-06-25T10:51:58Z
dc.date.issued2021-01-01
dc.description.abstractObjective: The aim of this study was to evaluate whether probiotics multi-strain formula affects the development of apical periodontitis (AP) induced in rats. Methodology: 16 Wistar rats were divided in two groups (n=8): rats with AP fed with regular diet (Control-C (CG)); rats with AP, fed with regular diet and supplemented with multi-strain formula (one billion colony-forming units (CFU)): GNC Probiotic Complex (PCG) (Lactobacillus acidophilus, Lactobacillus salivaris, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium animalis subs. lactis and Streptococcus thermofilus). AP was induced in the upper and lower first molars by dental pulp exposure to the oral environment. PCG was administered orally through gavage for 30 days during the AP development. After this period the animals were euthanized and the mandibles were removed and processed for histologic analysis, and immunochemical assays for interleukin (IL)-6, IL-10, IL-1β, RANKL, OPG, and TRAP. The Mann–Whitney U test and Student’s t test were performed (P<.05). Results: The CG showed more intense inflammatory infiltrate than the PCG group (P<.05). IL-1β, IL 6 and RANKL decreased in the PCG group compared with CG (P<.05). The IL-10 level increased in the PCG group (P<.05). The OPG level was similar in both groups (P>.05). The number of mature osteoclasts (TRAP-positive multinucleated cells) was lower in PCG group when compared to the CG (P<.05). Conclusion: Probiotic Complex modulates inflammation and bone resorption in apical periodontitis.en
dc.description.affiliationUniversidade Federal de Alagoas (UFAL) Faculdade de Odontologia Departamento de Odontologia Restauradora
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e Restauradora
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Odontologia Preventiva e Restauradora
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Odontologia de Araçatuba Departamento de Ciências Básicas
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2017/08312-2
dc.description.sponsorshipIdFAPESP: 2017/08314-5
dc.format.extent1-8
dc.identifierhttp://dx.doi.org/10.1590/1678-7757-2020-0483
dc.identifier.citationJournal of Applied Oral Science, v. 29, p. 1-8.
dc.identifier.doi10.1590/1678-7757-2020-0483
dc.identifier.fileS1678-77572021000100403.pdf
dc.identifier.issn1678-7765
dc.identifier.issn1678-7757
dc.identifier.scieloS1678-77572021000100403
dc.identifier.scopus2-s2.0-85100559039
dc.identifier.urihttp://hdl.handle.net/11449/207251
dc.language.isoeng
dc.relation.ispartofJournal of Applied Oral Science
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectApical periodontitis
dc.subjectBone resorption
dc.subjectInflammatory infiltrate
dc.subjectInterleukin
dc.subjectProbiotics
dc.titleDietary supplementation with multi-strain formula of probiotics modulates inflammatory and immunological markers in apical periodontitisen
dc.typeArtigo
unesp.author.orcid0000-0002-5755-1933[1]
unesp.author.orcid0000-0002-4125-8441[2]
unesp.author.orcid0000-0003-2348-7846[3]

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