Metal-organic frameworks for diagnosis and therapy of infectious diseases

dc.contributor.authorQuijia, Christian Rafael [UNESP]
dc.contributor.authorAlves, Renata Carolina [UNESP]
dc.contributor.authorHanck-Silva, Gilmar [UNESP]
dc.contributor.authorGalvão Frem, Regina Célia [UNESP]
dc.contributor.authorArroyos, Guilherme [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-05-01T08:44:40Z
dc.date.available2022-05-01T08:44:40Z
dc.date.issued2022-01-01
dc.description.abstractInfectious diseases are one of the leading cause of mortality and morbidity worldwide. Metal-Organic Frameworks (MOFs), which are porous coordination materials composed of bridging organic ligands and metallic ions or clusters, exhibits great potential to be used against several pathogens, such as bacteria, viruses, fungi and protozoa. MOFs can show sustained release capability, high surface area, adjustable pore size and structural flexibility, which makes them good candidates for new therapeutic systems. This review provides a detailed summary of the biological application of MOFs, focussing on diagnosis and treatment of infectious diseases. MOFs have been reported for usage as antimicrobial agents, drug delivery systems, therapeutic composites, nanozymes and phototherapies. Furthermore, different MOF-based biosensors have also been developed to detect specific pathogens by electrochemical, fluorometric and colorimetric assays. Finally, we present limitations and perspectives in this field.en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University UNESP
dc.description.affiliationInstitute of Chemistry São Paulo State University UNESP
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University UNESP
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University UNESP
dc.format.extent161-196
dc.identifierhttp://dx.doi.org/10.1080/1040841X.2021.1950120
dc.identifier.citationCritical Reviews in Microbiology, v. 48, n. 2, p. 161-196, 2022.
dc.identifier.doi10.1080/1040841X.2021.1950120
dc.identifier.issn1549-7828
dc.identifier.issn1040-841X
dc.identifier.scopus2-s2.0-85113464236
dc.identifier.urihttp://hdl.handle.net/11449/233438
dc.language.isoeng
dc.relation.ispartofCritical Reviews in Microbiology
dc.sourceScopus
dc.subjectantimicrobial agents
dc.subjectbiosensors
dc.subjectdrug delivery systems
dc.subjectMOFs
dc.subjectphototherapies
dc.subjecttherapeutics
dc.titleMetal-organic frameworks for diagnosis and therapy of infectious diseasesen
dc.typeResenha
unesp.author.orcid0000-0002-4370-8960[1]
unesp.author.orcid0000-0002-2901-8779[2]
unesp.author.orcid0000-0001-8114-6981[3]
unesp.author.orcid0000-0002-6698-0545[6]

Arquivos