THE EFFECT OF TUBEROINFUNDIBULAR DOPAMINERGIC-NEURONS ON PROLACTIN AND ALPHA-MELANOCYTE STIMULATING HORMONE-RELEASE

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Data

1991-01-01

Autores

Bedrandecastro, J. C.
Petrovic, S. L.
Khorram, O.
Mccann, S. M.

Título da Revista

ISSN da Revista

Título de Volume

Editor

Associação Brasileira de Divulgação Científica (ABRADIC)

Resumo

The effect of tubero-infundibular dopaminergic neurons (TIDA) on the release of prolactin (PRL) and alpha-melanocyte stimulating hormone (alpha-MSH) was studied in median eminence-lesioned (MEL) male rats (N = 6-28). Plasma PRL and alpha-MSH levels were significantly elevated 2 (86.1 +/- 19.8 and 505.1 +/- 19.1 ng/ml), 4 (278.7 +/- 15.5 and 487.4 +/- 125.1 ng/ml), 7 (116.2 +/- 16.2 and 495.8 +/- 62.6 ng/ml) and 14 (247.3 +/- 26.1 and 448.4 +/- 63.8 ng/ml) days after MEL when compared to sham-operated control animals (55.5 +/- 13.4 and 56.2 +/- 6.1 ng/ml, respectively). MEL altered plasma PRL and alpha-MSH levels in a differential manner, with a 1.5-to 5.0-fold increase in PRL and an 8.0-to 9.0-fold increase in alpha-MSH. The increase of alpha-MSH levels occurred abruptly and remained constant from days 2 to 14. These observations indicate that TIDA plays an important role in the pituitary release of PRL and alpha-MSH and provide evidence that the release of the two hormones occurs in a differential manner.

Descrição

Palavras-chave

PROLACTIN, ALPHA-MELANOCYTE STIMULATING HORMONE, TUBEROINFUNDIBULAR DOPAMINERGIC NEURONS, MEDIAN EMINENCE, PITUITARY

Como citar

Brazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 24, n. 10, p. 1059-1062, 1991.