The co-catalytic effect of chlorpromazine on peroxidase-mediated oxidation of melatonin: enhanced production of N-1-acetyl-N (2)-formyl-5-methoxykynuramine
dc.contributor.author | Ximenes, Valdecir Farias [UNESP] | |
dc.contributor.author | Rodrigues, Ana Paula [UNESP] | |
dc.contributor.author | Cabello, Claudio [UNESP] | |
dc.contributor.author | Menezes, Manoel Lima de [UNESP] | |
dc.contributor.author | Fernandes, João Roberto [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T13:12:55Z | |
dc.date.available | 2014-05-20T13:12:55Z | |
dc.date.issued | 2008-03-01 | |
dc.description.abstract | Accumulating evidence points to relationships between increased production of reactive oxygen or decreased antioxidant protection in schizophrenic patients. Chlorpromazine (CPZ), which remains a benchmark treatment for people with schizophrenia, has been described as a pro-oxidant compound. Because the antioxidant compound melatonin exerts protective effects against CPZ-induced liver disease in rats, in this investigation, our main objective was to study the effect of CPZ as a co-catalyst of peroxidase-mediated oxidation of melatonin. We found that melatonin was an excellent reductor agent of preformed CPZ cation radical (CPZ(center dot+)). The addition of CPZ during the horseradish peroxidase (HRP)-catalyzed oxidation of melatonin provoked a significant increase in the rate of oxidation and production of N-1-acetyl-N-2-formyl-5-methoxykynuramine (AFMK). Similar results were obtained using myeloperoxidase. The effect of CPZ on melatonin oxidation was rather higher at alkaline pH. At pH 9.0, the efficiency of oxidation of melatonin was 15 times higher and the production of AFMK was 30 times higher as compared with the assays in the absence of CPZ. We suggest that CPZ is able to exacerbate the rate of oxidation of melatonin by an electron transfer mechanism where CPZ(center dot+), generated during the peroxidase-catalyzed oxidation, is able to efficiently oxidize melatonin. | en |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Bauru, Dept Quim, BR-17033 Bauru, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Analises Clin, Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Bauru, Dept Quim, BR-17033 Bauru, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Analises Clin, Araraquara, SP, Brazil | |
dc.format.extent | 115-120 | |
dc.identifier | http://dx.doi.org/10.1111/j.1600-079X.2007.00497.x | |
dc.identifier.citation | Journal of Pineal Research. Oxford: Blackwell Publishing, v. 44, n. 2, p. 115-120, 2008. | |
dc.identifier.doi | 10.1111/j.1600-079X.2007.00497.x | |
dc.identifier.issn | 0742-3098 | |
dc.identifier.lattes | 4066413997908572 | |
dc.identifier.lattes | 0946361790812901 | |
dc.identifier.lattes | 4659698040759224 | |
dc.identifier.lattes | 8540599256820672 | |
dc.identifier.uri | http://hdl.handle.net/11449/824 | |
dc.identifier.wos | WOS:000253257400001 | |
dc.language.iso | eng | |
dc.publisher | Blackwell Publishing | |
dc.relation.ispartof | Journal of Pineal Research | |
dc.relation.ispartofjcr | 11.613 | |
dc.relation.ispartofsjr | 3,945 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | chlorpromazine | en |
dc.subject | horseradish peroxidase | en |
dc.subject | myeloperoxidase | en |
dc.subject | melatonin | en |
dc.subject | N-1-acetyl-N-2-formyl-5-methoxykynuramine | en |
dc.title | The co-catalytic effect of chlorpromazine on peroxidase-mediated oxidation of melatonin: enhanced production of N-1-acetyl-N (2)-formyl-5-methoxykynuramine | en |
dc.type | Artigo | |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dcterms.rightsHolder | Blackwell Publishing | |
unesp.author.lattes | 4066413997908572 | |
unesp.author.lattes | 0946361790812901 | |
unesp.author.lattes | 4659698040759224 | |
unesp.author.lattes | 8540599256820672 | |
unesp.author.orcid | 0000-0003-2636-3080[1] | |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.campus | Universidade Estadual Paulista (Unesp), Faculdade de Ciências, Bauru | pt |
unesp.department | Química - FC | pt |
unesp.department | Análises Clínicas - FCF | pt |
Arquivos
Licença do Pacote
1 - 2 de 2
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição:
Nenhuma Miniatura disponível
- Nome:
- license.txt
- Tamanho:
- 1.71 KB
- Formato:
- Item-specific license agreed upon to submission
- Descrição: