Antibody response to the 43 kDa glycoprotein of Paracoccidioides brasiliensis as a marker for the evaluation of patients under treatment

dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorBueno, J. P.
dc.contributor.authorAparecida Shikanai-Yasuda, M.
dc.contributor.authorStolf, A. M S
dc.contributor.authorMasuda, A.
dc.contributor.authorAmato Neto, V.
dc.contributor.authorFerreira, A. W.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T09:17:20Z
dc.date.available2014-05-27T09:17:20Z
dc.date.issued1990-09-14
dc.description.abstractSera of patients with paracoccidioidomycosis contained IgG-, IgA-, and IgM-specific antibodies to a 43 kDa antigen contained in the filtrate of a culture of Paracoccidioides brasiliensis. IgG- and IgA-specific antibodies were present in all observed patients. The IgM response was more frequent in acute cases, and the mean titers of IgG- and IgM-specific antibodies were higher in the acute forms. By the fourth month of chemotherapy, there was a decay of IgG, IgA, and IgM antibody titers to this antigen in acute cases, correlating with clinical improvement. The detection of IgG and IgA antibodies and the sequential determination of antibodies to the 43 kDa glycoprotein may be useful tools for serodiagnosis and evaluation of therapeutic efficacy.en
dc.format.extent200-206
dc.identifierhttp://www.ajtmh.org/content/43/2/200
dc.identifier.citationAmerican Journal of Tropical Medicine and Hygiene, v. 43, n. 2, p. 200-206, 1990.
dc.identifier.issn0002-9637
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.scopus2-s2.0-0024988032
dc.identifier.urihttp://hdl.handle.net/11449/64005
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Tropical Medicine and Hygiene
dc.relation.ispartofjcr2.564
dc.relation.ispartofsjr1,430
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectamphotericin b
dc.subjectketoconazole
dc.subjectsulfadiazine
dc.subjectsulfamethoxypyridazine
dc.subjectfungus
dc.subjecthuman
dc.subjecthuman cell
dc.subjectimmunoglobulin blood level
dc.subjectparacoccidioides brasiliensis
dc.subjectpriority journal
dc.subjectsouth american blastomycosis
dc.subjectAnalysis of Variance
dc.subjectAntibodies, Fungal
dc.subjectAntigens, Fungal
dc.subjectElectrophoresis, Polyacrylamide Gel
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectGlycoproteins
dc.subjectHuman
dc.subjectImmunoblotting
dc.subjectImmunoglobulin A
dc.subjectImmunoglobulin G
dc.subjectImmunoglobulin M
dc.subjectImmunoglobulins
dc.subjectMitosporic Fungi
dc.subjectParacoccidioides
dc.subjectParacoccidioidomycosis
dc.subjectSupport, Non-U.S. Gov't
dc.subjectFungi
dc.subjectParacoccidioides brasiliensis
dc.titleAntibody response to the 43 kDa glycoprotein of Paracoccidioides brasiliensis as a marker for the evaluation of patients under treatmenten
dc.typeArtigo
dcterms.licensehttp://www.ajtmh.org/site/misc/reprints_permissions.xhtml
dcterms.licensehttp://www.ajtmh.org/site/misc/ifora.xhtml
unesp.author.orcid0000-0002-8059-0826[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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