Topography-specific spindle frequency changes in Obstructive Sleep Apnea

dc.contributor.authorSchoenwald, Suzana V.
dc.contributor.authorCarvalho, Diego Z.
dc.contributor.authorde Santa-Helena, Emerson L.
dc.contributor.authorLemke, Ney [UNESP]
dc.contributor.authorGerhardt, Guenther J. L.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionHosp Clin Porto Alegre
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniv Caxias do Sul
dc.date.accessioned2014-05-20T13:49:41Z
dc.date.available2014-05-20T13:49:41Z
dc.date.issued2012-07-31
dc.description.abstractBackground: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (>= 13Hz) and slow(< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions.Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027).Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA.en
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biosci, Dept Phys & Biophys, Botucatu, SP, Brazil
dc.description.affiliationHosp Clin Porto Alegre, Div Pulm Med, Sleep Lab, BR-90035003 Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Sergipe, Dept Phys, Sao Cristovao, Brazil
dc.description.affiliationUniv Caxias do Sul, Dept Phys & Chem, BR-95001970 Caxias do Sul, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biosci, Dept Phys & Biophys, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 09/10382-2
dc.format.extent12
dc.identifierhttp://dx.doi.org/10.1186/1471-2202-13-89
dc.identifier.citationBmc Neuroscience. London: Biomed Central Ltd., v. 13, p. 12, 2012.
dc.identifier.doi10.1186/1471-2202-13-89
dc.identifier.fileWOS000311166100001.pdf
dc.identifier.issn1471-2202
dc.identifier.lattes7977035910952141
dc.identifier.urihttp://hdl.handle.net/11449/17713
dc.identifier.wosWOS:000311166100001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofBmc Neuroscience
dc.relation.ispartofjcr2.173
dc.relation.ispartofsjr1,120
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectTime seriesen
dc.subjectMatching pursuiten
dc.subjectEEGen
dc.subjectSleep spindlesen
dc.subjectOSAen
dc.titleTopography-specific spindle frequency changes in Obstructive Sleep Apneaen
dc.typeArtigo
dcterms.licensehttp://www.biomedcentral.com/about/license
dcterms.rightsHolderBiomed Central Ltd.
unesp.author.lattes7977035910952141
unesp.author.orcid0000-0001-7463-4303[4]
unesp.author.orcid0000-0002-8822-1638[2]
unesp.author.orcid0000-0002-8405-0966[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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