Cardiovascular effects of noradrenaline microinjected into the insular cortex of unanesthetized rats

dc.contributor.authorAlves, Fernando H. F.
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorResstel, Leonardo B. M.
dc.contributor.authorCorrea, Fernando M. A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:36Z
dc.date.available2014-05-20T13:25:36Z
dc.date.issued2011-02-24
dc.description.abstractThe insular cortex (IC) has been reported to be involved in central cardiovascular control. In the present study, we investigated the cardiovascular responses evoked by microinjection of noradrenaline into the IC as well as the central and peripheral mechanisms involved in their mediation. Microinjection of noradrenaline into the IC (3, 7, 10, 15,30 and 45 nmol/100 nL) caused long-lasting dose-related pressor and bradycardiac responses. The cardiovascular responses evoked by 15 nmol of noradrenaline were blocked by IC pretreatment with WB4101 or 5-methyl-urapidil, selective alpha(1)-adrenoceptor antagonists. IC pretreatment with either the selective alpha(2)-adrenoceptor antagonists RX821002 or the beta-adrenoceptor antagonist propranolol did not affect noradrenaline cardiovascular responses. Noradrenaline cardiovascular responses were mimicked by microinjection of the selective alpha(1)-adrenoceptor agonist phenylephrine into the IC, thus reinforcing the idea that alpha(1)-adrenoceptors mediate cardiovascular responses to noradrenaline microinjected into the IC. The pressor response to noradrenaline microinjection was potentiated by i.v. pretreatment with the ganglion blocker pentolinium and inhibited by i.v. pretreatment with the selective V(1)-vasopressin receptor antagonist dTyr(CH(2))(5)(Me)AVP. The bradycardiac response to noradrenaline microinjection into the IC was abolished by pretreatment with either pentolinium or the V(1)-vasopressin receptor antagonist, indicating its reflex origin. In conclusion, our results suggest that pressor response evoked by microinjection of noradrenaline into the IC involve the activation of IC alpha(1)-adrenoceptors to cause the release of vasopressin into the circulation. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUSP, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, UNESP, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, UNESP, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (FAEPA)
dc.description.sponsorshipIdCNPq: 870307/1997-5
dc.description.sponsorshipIdCNPq: 306381/2003-6
dc.description.sponsorshipIdCNPq: 505394/2003-0
dc.description.sponsorshipIdFAPESP: 06/57670-4
dc.format.extent90-98
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2010.11.002
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 160, n. 1-2, p. 90-98, 2011.
dc.identifier.doi10.1016/j.autneu.2010.11.002
dc.identifier.fileWOS000287989000014.pdf
dc.identifier.issn1566-0702
dc.identifier.lattes1117432571971568
dc.identifier.urihttp://hdl.handle.net/11449/8128
dc.identifier.wosWOS:000287989000014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.relation.ispartofjcr2.605
dc.relation.ispartofsjr0,902
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPrefrontal cortexen
dc.subjectBlood pressureen
dc.subjectHeart rateen
dc.subjectNoradrenergic neurotransmissionen
dc.subjectAdrenoceptorsen
dc.subjectVasopressinen
dc.titleCardiovascular effects of noradrenaline microinjected into the insular cortex of unanesthetized ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1117432571971568[2]
unesp.author.orcid0000-0002-1942-858X[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
WOS000287989000014.pdf
Tamanho:
576.14 KB
Formato:
Adobe Portable Document Format
Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: