Pancreas damage and intratracheal NiCl2 administration. Effects of nickel chloride.

Nenhuma Miniatura disponível

Data

1990-07-01

Autores

Novelli, E. L.
Sforcin, J. M.
Rodrigues, N. L.
Ribas, B. O.

Título da Revista

ISSN da Revista

Título de Volume

Editor

Resumo

Changes in activities of Cu-Zn superoxide dismutase (SOD- E.C.1.15.1.1.) and lactate dehydrogenase (LDH- E.C.1.1.1.27.) and levels of copper, total protein, triglycerides, phospholipids and total lipids were investigated in pancreas of rats after intratracheal administration of NiCl2 (8.4 mumol/kg). Nickel chloride induced increased SOD activity in pancreas and erythrocytes. This elevation was related to increased copper and decreased phospholipid content in pancreas of these animals. In conclusion, the ability of an animal to tolerate nickel chloride induced damage was governed by a delicate balance between the generation of cytotoxic agents and the various pancreas defense capabilities.

Descrição

Palavras-chave

copper, free radical, lactate dehydrogenase, lipid, nickel, nickel chloride, protein, superoxide, superoxide dismutase, animal, chemistry, drug effect, enzymology, injection, male, metabolism, pancreas, rat, rat strain, trachea, Animal, Copper, Free Radicals, Injections, Lactate Dehydrogenase, Lipids, Male, Nickel, Pancreas, Proteins, Rats, Rats, Inbred Strains, Superoxide Dismutase, Superoxides, Support, Non-U.S. Gov't, Trachea

Como citar

Boletin de estudios medicos y biologicos, v. 38, n. 3-4, p. 54-58, 1990.