Contribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesia

dc.contributor.authorCornelio, Alianda Maira [UNESP]
dc.contributor.authorNunes-de-Souza, Ricardo Luiz [UNESP]
dc.contributor.authorMorgan, Michael M.
dc.contributor.institutionWashington State Univ
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:34:45Z
dc.date.available2014-05-20T15:34:45Z
dc.date.issued2012-04-23
dc.description.abstractRats exposed to an elevated plus maze (EPM) with four open arms display antinociception while on the maze and hyperalgesia immediately upon removal. Little is known about the neural mechanisms underlying EPM-induced antinociception and the subsequent hyperalgesia except that the antinociception is not mediated by endogenous opioids. The objective of the present study was to test the hypothesis that endogenous cannabinoids and/or the rostral ventromedial medulla (RVM) contributes to EPM-induced antinociception. Administration of the CB1 receptor antagonist AM251 (1 mg/kg, i.p.) had no effect on baseline nociception to formalin administration into the hindpaw or on the antinociception produced by placing a rat on the open EPM. Likewise, inactivation of the RVM by microinjecting the GABA(A) receptor agonist muscimol (10 ng/0.5 mu L) had no effect on the antinociceptive effect of placing a rat in the EPM. However, RVM inactivation blocked the hyperalgesia produced upon removal from the EPM. Although distinct classes of RVM neurons inhibit and facilitate nociception, the present data demonstrate that the antinociception induced by the EPM and the subsequent hyperalgesia is mediated by distinct neural pathways. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationWashington State Univ, Dept Psychol, Vancouver, WA 98686 USA
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUFSCar UNESP, Programa Interinstituc Pos Grad Ciencias Fisiol, São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUFSCar UNESP, Programa Interinstituc Pos Grad Ciencias Fisiol, São Paulo, Brazil
dc.description.sponsorshipState of Washington Initiative
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.description.sponsorshipIdState of Washington Initiative: 171
dc.description.sponsorshipIdCNPq: 200639/2008-0
dc.format.extent80-86
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2012.02.037
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1450, p. 80-86, 2012.
dc.identifier.doi10.1016/j.brainres.2012.02.037
dc.identifier.fileWOS000303224600009.pdf
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/11449/42640
dc.identifier.wosWOS:000303224600009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectElevated plus mazeen
dc.subjectEnvironment-induced antinociceptionen
dc.subjectCannabinoiden
dc.subjectNociceptive modulationen
dc.subjectAnalgesiaen
dc.titleContribution of the rostral ventromedial medulla to post-anxiety induced hyperalgesiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0001-5762-2538[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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