Publicação:
Characterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peels

dc.contributor.authorJusto, Aline S.
dc.contributor.authorLemes, Bruna M.
dc.contributor.authorNunes, Bruna
dc.contributor.authorAntunes, Kevin A.
dc.contributor.authorCapote, Anna Claudia M O
dc.contributor.authorLipinski, Leandro C.
dc.contributor.authorCampagnoli, Eduardo B.
dc.contributor.authorEmiliano, Janaina
dc.contributor.authorMeurer, Eduardo C.
dc.contributor.authorEzemma, Ogechi
dc.contributor.authorMiot, Helio A. [UNESP]
dc.contributor.authorBeltrame, Flávio L
dc.contributor.authorWambier, Carlos G.
dc.contributor.institutionMedicine
dc.contributor.institutionDentistry
dc.contributor.institutionState University of Ponta Grossa
dc.contributor.institutionFederal University of Paraná
dc.contributor.institutionWarren Alpert Medical School of Brown University
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:30:42Z
dc.date.available2022-04-29T08:30:42Z
dc.date.issued2021-07-01
dc.description.abstractBACKGROUND: Croton oil (CO) is used by dermatologists and plastic surgeons in deep chemical peels. It is mixed with phenol, water, and a soap in Baker-Gordon's or Hetter's formulas. There is controversy as to whether CO or phenol is the active agent in the dermal effect of deep chemical peels. OBJECTIVE: To better clarify the role of CO in deep peels, by identification of active compounds in commercially available CO in the United States and biological effects in vivo. MATERIALS AND METHODS: Liquid chromatography-tandem mass spectrometry on CO and a domestic pig model experiment using 3 different formulas: G1: 5% Septisol (SEP), G2: 1.6% croton oil in 35% phenol with 5% SEP, and G3: 35% phenol with 5% SEP. RESULTS: Liquid chromatography-tandem mass spectrometry indicated the presence of phorbol esters. G1 was null overall. Extent of the coagulative necrosis: G2 > G3. Vascular ectasia: G2 > G3. Inflammation pattern: intense neutrophilic inflammatory band in G2 versus mild, sparse, perivascular mononuclear cell infiltrate in G3. Neocollagenesis: pronounced in G2, negligible in G3. CONCLUSION: Coagulative necrosis of the epidermis, superficial fibroblasts, and vasculature can be attributed to the action of phenol. Phorbol esters on CO could be responsible for the dense deep acute inflammation and the distinctive neocollagenesis.en
dc.description.affiliationDepartments of Pharmaceutical Sciences
dc.description.affiliationMedicine
dc.description.affiliationDentistry
dc.description.affiliationLaboratory of Research of SEBISA State University of Ponta Grossa
dc.description.affiliationLaboratory Fenn of Massachusetts Spectrometry Federal University of Paraná
dc.description.affiliationDepartment of Dermatology Warren Alpert Medical School of Brown University
dc.description.affiliationDepartment of Dermatology and Radiotherapy Sao Paulo State University (UNESP)
dc.description.affiliationUnespDepartment of Dermatology and Radiotherapy Sao Paulo State University (UNESP)
dc.format.extent944-946
dc.identifierhttp://dx.doi.org/10.1097/DSS.0000000000002990
dc.identifier.citationDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], v. 47, n. 7, p. 944-946, 2021.
dc.identifier.doi10.1097/DSS.0000000000002990
dc.identifier.issn1524-4725
dc.identifier.scopus2-s2.0-85110251582
dc.identifier.urihttp://hdl.handle.net/11449/229142
dc.language.isoeng
dc.relation.ispartofDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
dc.sourceScopus
dc.titleCharacterization of the Activity of Croton tiglium Oil in Hetter's Very Heavy Phenol-Croton Oil Chemical Peelsen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentDermatologia e Radioterapia - FMBpt

Arquivos