Publicação:
Management of Osteonecrosis of the Jaws in Patients With History of Bisphosphonates Therapy

dc.contributor.authorAntonini, Fernando
dc.contributor.authorSilva Pereira, Cassiano Costa [UNESP]
dc.contributor.authorParente, Eduardo Varela
dc.contributor.authorAzambuja, Fabiano Goulart
dc.contributor.institutionLSUHSC Sch Dent
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade do Estado do Rio de Janeiro (UERJ)
dc.date.accessioned2014-05-20T15:31:19Z
dc.date.available2014-05-20T15:31:19Z
dc.date.issued2010-11-01
dc.description.abstractBisphosphonates are compounds used in the treatment of various metabolic and malignant bone diseases. The relation between the use of bisphosphonates and ostenonecrosis of the jaws as an adverse effect of the drug has been intensely discussed during the last few years, and up to this moment, there is no consensus concerning an ideal treatment modality for this condition. Nevertheless, there is an agreement among researchers that the standard goal for controlling jaw osteonecrosis is to prevent it. Otherwise, the rationale for a randomized controlled trial is that current treatment has proven to be suboptimal, and no consensus has been reached yet on the best strategies to repair the exposed bone once bone necrosis is developed. This article is focused on reporting a case of moderate osteonecrosis of the upper jaw induced by bisphosphonates and discusses a possible role for surgical debridement associated to platelet-rich plasma, hyperbaric oxygen therapy, and the cessation of the bisphosphonate use in managing this type of lesion. Moreover, the dentist, the oral surgeon, and the oncologist need to work together to reach better outcomes.en
dc.description.affiliationLSUHSC Sch Dent, Dept Oral Biol, Aracatuba, Brazil
dc.description.affiliationSão Paulo State Univ Julio de Mesquita Filho, Aracatuba Sch Dent, Aracatuba, Brazil
dc.description.affiliationUniversidade do Estado do Rio de Janeiro (UERJ), UERJ Sch Dent, Rio de Janeiro, Brazil
dc.description.affiliationUnespSão Paulo State Univ Julio de Mesquita Filho, Aracatuba Sch Dent, Aracatuba, Brazil
dc.format.extent1962-1966
dc.identifierhttp://dx.doi.org/10.1097/SCS.0b013e3181f4ee4e
dc.identifier.citationJournal of Craniofacial Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 6, p. 1962-1966, 2010.
dc.identifier.doi10.1097/SCS.0b013e3181f4ee4e
dc.identifier.issn1049-2275
dc.identifier.urihttp://hdl.handle.net/11449/40483
dc.identifier.wosWOS:000284829800077
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Craniofacial Surgery
dc.relation.ispartofjcr0.772
dc.relation.ispartofsjr0,448
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectOsteonecrosisen
dc.subjectbisphosphonatesen
dc.subjecthyperbaric oxygen therapyen
dc.subjectplatelet-rich plasmaen
dc.titleManagement of Osteonecrosis of the Jaws in Patients With History of Bisphosphonates Therapyen
dc.typeArtigo
dcterms.licensehttp://edmgr.ovid.com/spine/accounts/copyrightTransfer.pdf
dcterms.rightsHolderLippincott Williams & Wilkins
dspace.entity.typePublication

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