Publicação: Management of Osteonecrosis of the Jaws in Patients With History of Bisphosphonates Therapy
dc.contributor.author | Antonini, Fernando | |
dc.contributor.author | Silva Pereira, Cassiano Costa [UNESP] | |
dc.contributor.author | Parente, Eduardo Varela | |
dc.contributor.author | Azambuja, Fabiano Goulart | |
dc.contributor.institution | LSUHSC Sch Dent | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade do Estado do Rio de Janeiro (UERJ) | |
dc.date.accessioned | 2014-05-20T15:31:19Z | |
dc.date.available | 2014-05-20T15:31:19Z | |
dc.date.issued | 2010-11-01 | |
dc.description.abstract | Bisphosphonates are compounds used in the treatment of various metabolic and malignant bone diseases. The relation between the use of bisphosphonates and ostenonecrosis of the jaws as an adverse effect of the drug has been intensely discussed during the last few years, and up to this moment, there is no consensus concerning an ideal treatment modality for this condition. Nevertheless, there is an agreement among researchers that the standard goal for controlling jaw osteonecrosis is to prevent it. Otherwise, the rationale for a randomized controlled trial is that current treatment has proven to be suboptimal, and no consensus has been reached yet on the best strategies to repair the exposed bone once bone necrosis is developed. This article is focused on reporting a case of moderate osteonecrosis of the upper jaw induced by bisphosphonates and discusses a possible role for surgical debridement associated to platelet-rich plasma, hyperbaric oxygen therapy, and the cessation of the bisphosphonate use in managing this type of lesion. Moreover, the dentist, the oral surgeon, and the oncologist need to work together to reach better outcomes. | en |
dc.description.affiliation | LSUHSC Sch Dent, Dept Oral Biol, Aracatuba, Brazil | |
dc.description.affiliation | São Paulo State Univ Julio de Mesquita Filho, Aracatuba Sch Dent, Aracatuba, Brazil | |
dc.description.affiliation | Universidade do Estado do Rio de Janeiro (UERJ), UERJ Sch Dent, Rio de Janeiro, Brazil | |
dc.description.affiliationUnesp | São Paulo State Univ Julio de Mesquita Filho, Aracatuba Sch Dent, Aracatuba, Brazil | |
dc.format.extent | 1962-1966 | |
dc.identifier | http://dx.doi.org/10.1097/SCS.0b013e3181f4ee4e | |
dc.identifier.citation | Journal of Craniofacial Surgery. Philadelphia: Lippincott Williams & Wilkins, v. 21, n. 6, p. 1962-1966, 2010. | |
dc.identifier.doi | 10.1097/SCS.0b013e3181f4ee4e | |
dc.identifier.issn | 1049-2275 | |
dc.identifier.uri | http://hdl.handle.net/11449/40483 | |
dc.identifier.wos | WOS:000284829800077 | |
dc.language.iso | eng | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.relation.ispartof | Journal of Craniofacial Surgery | |
dc.relation.ispartofjcr | 0.772 | |
dc.relation.ispartofsjr | 0,448 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Osteonecrosis | en |
dc.subject | bisphosphonates | en |
dc.subject | hyperbaric oxygen therapy | en |
dc.subject | platelet-rich plasma | en |
dc.title | Management of Osteonecrosis of the Jaws in Patients With History of Bisphosphonates Therapy | en |
dc.type | Artigo | |
dcterms.license | http://edmgr.ovid.com/spine/accounts/copyrightTransfer.pdf | |
dcterms.rightsHolder | Lippincott Williams & Wilkins | |
dspace.entity.type | Publication |
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