Isotretinoin Oxidation and Electroanalysis in a Pharmaceutical Drug Using a Boron-doped Diamond Electrode
Nenhuma Miniatura disponível
Data
2016-11-01
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Isotretinoin redox behaviour, by voltammetry, at the cathodic pre-treated boron doped diamond electrode by cyclic, differential pulse and square wave voltammetry, and by spectrophotometry in a wide pH range, was investigated. The isotretinoin oxidation was an irreversible, diffusion-controlled process, occurred in a three-step cascade mechanism, and the isotretinoin diffusion coefficient D13-cis-RA=7.35×10−6 cm2 s−1, was calculated. The UV-Vis isotretinoin maximum absorption was pH-dependent. The detection limits LOD=0.53 μM, by differential pulse voltammetry, and LOD=0.38 μM, by UV-Vis spectroscopy, were obtained. The isotretinoin in the pharmaceutical drug Roacutan®, using differential pulse voltammetry, was determined.
Descrição
Palavras-chave
Idioma
Inglês
Como citar
Electroanalysis, v. 28, n. 11, p. 2709-2715, 2016.
