Riscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicos

dc.contributor.authorLucio, Lorena M.C. [UNESP]
dc.contributor.authorBraz, Mariana G. [UNESP]
dc.contributor.authordo Nascimento Junior, Paulo [UNESP]
dc.contributor.authorBraz, José Reinaldo C. [UNESP]
dc.contributor.authorBraz, Leandro G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:12:54Z
dc.date.available2018-12-11T17:12:54Z
dc.date.issued2018-01-01
dc.description.abstractBackground and objectives The waste anesthetic gases (WAGs) present in the ambient air of operating rooms (OR), are associated with various occupational hazards. This paper intends to discuss occupational exposure to WAGs and its impact on exposed professionals, with emphasis on genetic damage and oxidative stress. Content Despite the emergence of safer inhaled anesthetics, occupational exposure to WAGs remains a current concern. Factors related to anesthetic techniques and anesthesia workstations, in addition to the absence of a scavenging system in the OR, contribute to anesthetic pollution. In order to minimize the health risks of exposed professionals, several countries have recommended legislation with maximum exposure limits. However, developing countries still require measurement of WAGs and regulation for occupational exposure to WAGs. WAGs are capable of inducing damage to the genetic material, such as DNA damage assessed using the comet assay and increased frequency of micronucleus in professionals with long‐term exposure. Oxidative stress is also associated with WAGs exposure, as it induces lipid peroxidation, oxidative damage in DNA, and impairment of the antioxidant defense system in exposed professionals. Conclusions The occupational hazards related to WAGs including genotoxicity, mutagenicity and oxidative stress, stand as a public health issue and must be acknowledged by exposed personnel and responsible authorities, especially in developing countries. Thus, it is urgent to stablish maximum safe limits of concentration of WAGs in ORs and educational practices and protocols for exposed professionals.en
dc.description.affiliationUniversidade Estadual Paulista (Unesp) Faculdade de Medicina de Botucatu Departamento de Anestesiologia
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp) Faculdade de Medicina de Botucatu Departamento de Anestesiologia
dc.format.extent33-41
dc.identifierhttp://dx.doi.org/10.1016/j.bjan.2017.05.001
dc.identifier.citationBrazilian Journal of Anesthesiology, v. 68, n. 1, p. 33-41, 2018.
dc.identifier.doi10.1016/j.bjan.2017.05.001
dc.identifier.file2-s2.0-85021245681.pdf
dc.identifier.issn1806-907X
dc.identifier.issn0034-7094
dc.identifier.lattes8745358989680600
dc.identifier.orcid0000-0002-2323-9159
dc.identifier.scopus2-s2.0-85021245681
dc.identifier.urihttp://hdl.handle.net/11449/174797
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofBrazilian Journal of Anesthesiology
dc.relation.ispartofsjr0,320
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEnvironment pollution
dc.subjectGenomic instability
dc.subjectGenotoxicity testing
dc.subjectInhaled anesthetics
dc.subjectOccupational exposure
dc.subjectOxidative stress
dc.titleRiscos ocupacionais, danos no material genético e estresse oxidativo frente à exposição aos resíduos de gases anestésicospt
dc.title.alternativeOccupational hazards, DNA damage, and oxidative stress on exposure to waste anesthetic gasesen
dc.typeArtigo
unesp.author.lattes8745358989680600[3]
unesp.author.orcid0000-0002-2323-9159[3]

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