Pharmacokinetic and pharmacodynamics of sodium diclofenac (topical and Im) associated with laser photobiomodulation on skeletal muscle strain in rats

dc.contributor.authorDe Paiva Carvalho, Rodrigo Leal [UNESP]
dc.contributor.authorLeonardo, P. S.L.M.
dc.contributor.authorMendes, Gustavo Duarte
dc.contributor.authorLima, Fernanda Púpio Silva
dc.contributor.authorLima, Mário Oliveira
dc.contributor.authorMarcos, Rodrigo Labat
dc.contributor.authorLopes-Martins, Rodrigo Alvaro Brandão
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNIVAP
dc.contributor.institutionPrograma de Pós-Graduação em Saúde e Meio Ambiente
dc.contributor.institutionFaculdade de Medicina São Leopoldo Mandic
dc.contributor.institutionUniversidade Nove de Julho
dc.date.accessioned2019-10-06T15:43:49Z
dc.date.available2019-10-06T15:43:49Z
dc.date.issued2019-01-01
dc.description.abstractPurpose. The practice of physical activities is considered a primary factor for the maintenance of good health status. However, exhaustive or unusual physical activities can lead to muscle injuries. Several treatments are used to recover muscle injuries; however, systemic NSAIDs often result in serious adverse events. In this study, we aimed to investigate the association of laser therapy (LLLT) and topical diclofenac, evaluating the kinetics of the drug and its pharmacodynamic effect in stretching-induced muscle injury in rats. Methods. Male Wistar rats weighing 200 g were randomized and divided into groups of 6 animals. Plasma concentrations of diclofenac were quantified by mass spectrometry at different times (15 min to 24 hours) in all animals. The laser energy used was 3 Joules (830 nm; 100 mW, 30s). Treated groups received diclofenac at the dose of 1 mg/kg IM or topically applied with or without laser therapy. The electric stimulation was used to study the functional status of the muscles. Results. After topical administration of diclofenac, the peak plasma concentration (t max) occurred for 30 minutes in the irradiated group and 4 hours in the nonirradiated group. The AUC (0-24 hs) was 442 (ng/h/mL -1 ) in the nonirradiated group and 712 (ng/h/mL -1 ) in the irradiated group. Conclusion. LLLT was effective to provide a significant improvement in functional patterns. Taken together, our results demonstrate the synergistic effect between LLLT and topical diclofenac in muscle injury induced by stretching in rats.en
dc.description.affiliationDepartment of Physical Education Universidade Estadual Paulista UNESP
dc.description.affiliationLaboratory of Biophotonics and Experimental Therapeutics Instituto de Pesquisa and Desenvolvimento IP and D Universidade do Vale do Paraíba UNIVAP
dc.description.affiliationUniversidade Metropolitana de Santos-UNIMES Programa de Pós-Graduação em Saúde e Meio Ambiente
dc.description.affiliationFaculdade de Medicina São Leopoldo Mandic
dc.description.affiliationLaboratory of Sensory Motor Rehabilitation Instituto de Pesquisa and Desenvolvimento-IP and D Universidade do Vale do Paraíba UNIVAP
dc.description.affiliationPostgraduate Program in Biophotonics Applied to Health Sciences Universidade Nove de Julho
dc.description.affiliationUnespDepartment of Physical Education Universidade Estadual Paulista UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.identifierhttp://dx.doi.org/10.1155/2019/2782709
dc.identifier.citationInternational Journal of Photoenergy, v. 2019.
dc.identifier.doi10.1155/2019/2782709
dc.identifier.issn1687-529X
dc.identifier.issn1110-662X
dc.identifier.scopus2-s2.0-85065859806
dc.identifier.urihttp://hdl.handle.net/11449/187677
dc.language.isoeng
dc.relation.ispartofInternational Journal of Photoenergy
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titlePharmacokinetic and pharmacodynamics of sodium diclofenac (topical and Im) associated with laser photobiomodulation on skeletal muscle strain in ratsen
dc.typeArtigo

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