Human platelets antigens influence the viral load of platelets after the interaction of the platelets with HCV and HIV in vitro
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Tommasini Grotto, Rejane Maria [UNESP]
Cantao, Natalia Mirele [UNESP]
Padovani, Juliana Lara [UNESP]
Souza, Lenice do Rosario de [UNESP]
Silva, Giovanni Faria [UNESP]
Ferrasi, Adriana Camargo [UNESP]
Moura Campos Pardini, Maria Ines de [UNESP]
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Soc Brasileira Medicina Tropical
Introduction: In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. Methods: Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. Results: The viral load in the platelets after exposure to the virus was higher in the HIV exposure than in the HCV exposure. Conclusions: HIV-platelet ligation could be more efficient than HCV-platelet interaction. Further, the HPA-1b allele seems to influence the interaction of platelets with HCV.
Hepatitis C virus, Human platelets antigen polymorphisms, Human immunodeficiency virus
Revista Da Sociedade Brasileira De Medicina Tropical. Brasilia: Soc Brasileira Medicina Tropical, v. 49, n. 4, p. 491-493, 2016.