Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina

Grillo, Renato [UNESP]; Melo, Nathalie F. S. de [UNESP]; Fraceto, Leonardo Fernandes [UNESP]; Brito, Charles L.; Trossini, Gustavo H. G.; Menezes, Carla M. S.; Ferreira, Elizabeth Igne; Moraes, Carolina Morales

Caracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrina

Arquivos

S0100-40422008000200019.pdf (349.17 KB)

Data

2008-01-01

Autores

Grillo, Renato

Melo, Nathalie F. S. de

Fraceto, Leonardo Fernandes

Brito, Charles L.

Trossini, Gustavo H. G.

Menezes, Carla M. S.

Ferreira, Elizabeth Igne

Moraes, Carolina Morales

Editor

Sociedade Brasileira de Química

Tipo

Artigo

Direito de acesso

Acesso aberto

Resumo

Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.