Increased natural killer activity does not prevent progression of experimental kala-azar

dc.contributor.authorSartori, Alexandria [UNESP]
dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.authorBaruzzi, Nelson [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:49Z
dc.date.available2014-05-27T11:19:49Z
dc.date.issued1999-12-01
dc.description.abstractKala-azar is the visceral form of leishmaniasis and it is caused by intracellular parasites from the complex Leishmania donovani. Golden hamster (Mesocricetus auratus) infected with Leishmania donovani develop a disease very similar to human Kala-azar. There is conspicuous hipergammaglobulinaemia and their T cells do not respond to stimulation with parasite antigens. We used this experimental model to evaluate the natural killer (NK) activity during the initial phase of the disease. Outbred hamsters infected by intravenous route with 5.106 amastigotes of L. donovani 1S showed a concurrent increase in the spleen weight and in the spleen cell number. Using the single cell assay we detected a significant increase in the percentage of NK effector cells on the 4th day of infection. Imprints from spleen and liver showed at days 14 and 28 a significant increase in the parasite burden. These results show that the increased NK activity in the beginning of the infection was not able to restrain the progression of the disease in this experimental model.en
dc.description.affiliationDepartment of Microbiology Institute of Biological Sciences S. Paulo State University (UNESP), Botucatu, SP
dc.description.affiliationHematology Center Medical School of UNESP, Botucatu, SP
dc.description.affiliationDepto. de Microbiologia Instituto de Biociências UNESP, 18618-000 Botucatu, SP
dc.description.affiliationUnespDepartment of Microbiology Institute of Biological Sciences S. Paulo State University (UNESP), Botucatu, SP
dc.description.affiliationUnespHematology Center Medical School of UNESP, Botucatu, SP
dc.description.affiliationUnespDepto. de Microbiologia Instituto de Biociências UNESP, 18618-000 Botucatu, SP
dc.format.extent215-219
dc.identifierhttp://dx.doi.org/10.1590/S0036-46651999000400002
dc.identifier.citationRevista do Instituto de Medicina Tropical de Sao Paulo, v. 41, n. 4, p. 215-219, 1999.
dc.identifier.doi10.1590/S0036-46651999000400002
dc.identifier.file2-s2.0-0033155342.pdf
dc.identifier.issn0036-4665
dc.identifier.lattes4977572416129527
dc.identifier.lattes8845835550637809
dc.identifier.lattes6486557387397806
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.scieloS0036-46651999000400002
dc.identifier.scopus2-s2.0-0033155342
dc.identifier.urihttp://hdl.handle.net/11449/65972
dc.language.isoeng
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo
dc.relation.ispartofjcr1.489
dc.relation.ispartofsjr0,669
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectKala-azar
dc.subjectLeismania donovani
dc.subjectNatural killer activity
dc.subjectanimal
dc.subjectdisease course
dc.subjectdisease model
dc.subjectfemale
dc.subjecthamster
dc.subjectimmunology
dc.subjectLeishmania donovani
dc.subjectliver
dc.subjectlymphocyte count
dc.subjectlymphocyte subpopulation
dc.subjectnatural killer cell
dc.subjectparasitology
dc.subjectspleen
dc.subjectvisceral leishmaniasis
dc.subjectAnimals
dc.subjectCricetinae
dc.subjectDisease Models, Animal
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectKiller Cells, Natural
dc.subjectLeishmaniasis, Visceral
dc.subjectLiver
dc.subjectLymphocyte Count
dc.subjectLymphocyte Subsets
dc.subjectSpleen
dc.titleIncreased natural killer activity does not prevent progression of experimental kala-azaren
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rimtsp/paboutj.htm
unesp.author.lattes4977572416129527
unesp.author.lattes6486557387397806
unesp.author.lattes8845835550637809[2]
unesp.author.orcid0000-0002-4292-3298[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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