Rice (Oryza sativa L.) bran preserves cardiac function by modulating pro-inflammatory cytokines and redox state in the myocardium from obese rats

dc.contributor.authorGarcia, Jéssica Leite [UNESP]
dc.contributor.authorVileigas, Danielle Fernandes
dc.contributor.authorGregolin, Cristina Schmitt [UNESP]
dc.contributor.authorCosta, Mariane Róvero [UNESP]
dc.contributor.authorFrancisqueti-Ferron, Fabiane Valentini [UNESP]
dc.contributor.authorFerron, Artur Junio Togneri [UNESP]
dc.contributor.authorDe Campos, Dijon Henrique Salomé [UNESP]
dc.contributor.authorMoreto, Fernando [UNESP]
dc.contributor.authorMinatel, Igor Otávio [UNESP]
dc.contributor.authorBazan, Silméia Garcia Zanati [UNESP]
dc.contributor.authorCorrêa, Camila Renata [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T08:45:59Z
dc.date.available2022-04-29T08:45:59Z
dc.date.issued2022-03-01
dc.description.abstractPurpose: This study aimed to evaluate the effect of rice bran (RB) supplementation to a high-sugar fat (HSF) diet on cardiac dysfunction in an experimental obesity model. Methods: Male Wistar rats were distributed into three groups: control, high-sugar fat, and high-sugar fat supplemented with 11% RB for 20 weeks. Results: HSF diet promoted obesity and metabolic complications. Obese rats showed cardiac structural and functional impairment associated with high levels of interleukin-6, tumoral necrosis factor alpha, and malondialdehyde, and decreased activity of superoxide dismutase and catalase in the myocardium. RB supplementation was able to mitigate obesity and its metabolic alterations in HSF diet-fed animals. Moreover, the RB also prevented structural and functional damage, inflammation, and redox imbalance in the heart of these animals. Conclusion: This study suggests that RB supplementation prevents cardiac dysfunction in rats fed on HSF by modulating systemic metabolic complications and inflammation and oxidative stress in the myocardium, representing potential alternative therapy.en
dc.description.affiliationSão Paulo State University (UNESP) Medical School
dc.description.affiliationDepartment of Biochemistry Institute of Chemistry University of São Paulo (USP)
dc.description.affiliationSão Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationUnespSão Paulo State University (UNESP) Medical School
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Biosciences
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 167750/2018-6
dc.description.sponsorshipIdFAPESP: 2018/15294-3
dc.format.extent901-913
dc.identifierhttp://dx.doi.org/10.1007/s00394-021-02691-0
dc.identifier.citationEuropean Journal of Nutrition, v. 61, n. 2, p. 901-913, 2022.
dc.identifier.doi10.1007/s00394-021-02691-0
dc.identifier.issn1436-6215
dc.identifier.issn1436-6207
dc.identifier.scopus2-s2.0-85116984540
dc.identifier.urihttp://hdl.handle.net/11449/231529
dc.language.isoeng
dc.relation.ispartofEuropean Journal of Nutrition
dc.sourceScopus
dc.subjectCardiac remodeling
dc.subjectInflammation
dc.subjectInsulin resistance
dc.subjectOxidative stress
dc.subjectRice bran
dc.subjectWestern diet
dc.titleRice (Oryza sativa L.) bran preserves cardiac function by modulating pro-inflammatory cytokines and redox state in the myocardium from obese ratsen
dc.typeArtigo
unesp.author.orcid0000-0002-3670-243X[1]
unesp.author.orcid0000-0002-0551-0435[2]
unesp.author.orcid0000-0002-9175-9076[3]
unesp.author.orcid0000-0002-2004-3097[4]
unesp.author.orcid0000-0003-2910-4308[5]
unesp.author.orcid0000-0001-7089-3033[6]
unesp.author.orcid0000-0002-4933-0604[7]
unesp.author.orcid0000-0002-4028-0014[8]
unesp.author.orcid0000-0002-9922-2871[9]
unesp.author.orcid0000-0002-0607-8189[10]
unesp.author.orcid0000-0001-8493-5329[11]

Arquivos