Publicação:
Bisphenol A Exposure Impairs Epididymal Development during the Peripubertal Period of Rats: Inflammatory Profile and Tissue Changes

dc.contributor.authorOgo, Fernanda Mithie
dc.contributor.authorde Lion Siervo, Glaucia Eloisa Munhoz
dc.contributor.authorStaurengo-Ferrari, Larissa
dc.contributor.authorde Oliveira Mendes, Leonardo [UNESP]
dc.contributor.authorLuchetta, Nicla Renata
dc.contributor.authorVieira, Henrique Rodrigues
dc.contributor.authorFattori, Victor
dc.contributor.authorVerri, Waldiceu Aparecido
dc.contributor.authorScarano, Wellerson Rodrigo [UNESP]
dc.contributor.authorFernandes, Glaura Scantamburlo Alves
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:34:20Z
dc.date.available2018-12-11T17:34:20Z
dc.date.issued2018-02-01
dc.description.abstractBisphenol A (BPA) is a synthetic non-steroidal oestrogen used in the production of plastics. BPA can cause alterations in the endocrine system of human beings and animals at varied stages of development. During puberty, altered morphological, sexual behaviour and completion of the epididymal development occur. Therefore, this study aimed to evaluate the effects of BPA on epididymal development during the peripubertal period of rats. Male Wistar rats were treated with BPA via gavage at doses of 20 μg/kg or 200 μg/kg per day [post-natal day (PND] 36–66). The control group received the vehicles under the same conditions. Feed and water were provided ad libitum. On PND 67, the epididymis was removed, weighed, divided into caput/corpus and cauda sections. It was then used for sperm count determination; histopathological and stereological evaluation; inflammatory cell enzymatic profiling (myeloperoxidase activity – MPO; N-acetylglucosaminidase – NAG); immunohistochemistry for IL-6; and evaluation of superoxide anion levels and malondialdehyde (MDA). Exposure to BPA at 200 μg/kg caused a significant increase of MPO activity and immunoreactivity to IL-6 (interleukin-6) as well as remodelling of tissue components in the caput/corpus and cauda regions of the epididymis. Under these experimental conditions, it is concluded that BPA alters post-natal epididymal development.en
dc.description.affiliationDepartment of General Biology Biological Sciences Center State University of Londrina – UEL
dc.description.affiliationDepartment of Pathological Sciences Biological Sciences Center State University of Londrina – UEL
dc.description.affiliationDepartment of Morphology Institute of Biosciences UNESP – Paulista State University
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences UNESP – Paulista State University
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent262-270
dc.identifierhttp://dx.doi.org/10.1111/bcpt.12894
dc.identifier.citationBasic and Clinical Pharmacology and Toxicology, v. 122, n. 2, p. 262-270, 2018.
dc.identifier.doi10.1111/bcpt.12894
dc.identifier.issn1742-7843
dc.identifier.issn1742-7835
dc.identifier.scopus2-s2.0-85030090014
dc.identifier.urihttp://hdl.handle.net/11449/179240
dc.language.isoeng
dc.relation.ispartofBasic and Clinical Pharmacology and Toxicology
dc.relation.ispartofsjr0,655
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.titleBisphenol A Exposure Impairs Epididymal Development during the Peripubertal Period of Rats: Inflammatory Profile and Tissue Changesen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMorfologia - IBBpt

Arquivos