Antineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrode
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2012-04-01
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Wiley-v C H Verlag Gmbh
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Methotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH-dependent, diffusion-controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7-hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH-dependent, quasi-reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product.
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Electroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 4, p. 917-923, 2012.