Cartilage Reconstruction Using Self-anchoring Implant with Functional Gradient

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Laurenti, Karen Cristina
Albuquerque Haach, Lourdes Cristina de
Santos, Arnaldo Rodrigues dos
Domingos de Almeida Rollo, Joao Manuel
Menezes Reiff, Rodrigo Bezerra de
Minarelli Gaspar, Ana Maria [UNESP]
Purquerio, Benedito de Moraes
Fortulan, Carlos Alberto

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Univ Fed Sao Carlos, Dept Engenharia Materials


This study presents an innovative and original biomaterial designed to substitute for articular cartilage and mimic its mechanical behavior, including elastic cushioning and the characteristics of fiber-reinforced gel. The material was composed of polyurethane and bioglass microfiber 45S5. It was designed to present a tribological surface to the cartilage of the tibial plateau, and to convert over a functional gradient to an osteointegrable region for self-anchorage to the subchondral bone. The biomaterial samples showed no toxicity and promoted cell spreading. Subsequent in vivo studies in rabbits demonstrated the formation of a rigid structure similar to bone trabeculae in the distal region of the tribological surface of the implant. The tribological surface of the proximal region showed a fibrocartilaginous tissue with highly vascularized chondrocytes, thus validating the proposed concept for the design of the implant incorporating a functional gradient and auto-stability.



osteochondral defect, polyurethane, microfiber 45S5 bioglass, cartilage repair, functional gradient

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Materials Research-ibero-american Journal Of Materials. Sao Carlos: Univ Fed Sao Carlos, Dept Engenharia Materials, v. 17, n. 3, p. 638-649, 2014.