Influence of physical preconditioning on the responsiveness of rat pulmonary artery after pulmonary ischemia/reperfusion

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dc.contributor.authorDelbin, Maria Andréia [UNESP]
dc.contributor.authorMoraes, Camila [UNESP]
dc.contributor.authorCamargo, Enilton
dc.contributor.authorMussi, Ricardo K.
dc.contributor.authorAntunes, Edson
dc.contributor.authorde Nucci, Gilberto
dc.contributor.authorZanesco, Angelina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-27T11:22:30Z
dc.date.available2014-05-27T11:22:30Z
dc.date.issued2007-07-01
dc.description.abstractThe aim of this work was to evaluate the effect of physical preconditioning in the responsiveness of rat pulmonary rings submitted to lung ischemia/reperfusion (IR). Wistar rats were divided into three groups: Sedentary sham-operated (SD/SHAM); sedentary submitted to ischemia/reperfusion (SD/IR) and trained submitted to ischemia/reperfusion (TR/IR) animals. Exercise training consisted in sessions of 60 min/day running sessions, 5 days/week for 8 weeks. Left pulmonary IR was performed by occluding for 90 min and reperfusing for 120 min. After that, pulmonary arteries were isolated and concentration-response curves to acetylcholine (ACh), histamine (HIST), sodium nitroprusside (SNP), phenylephrine and U46619 were obtained. Neither potency (- log EC50) nor maximal responses (Emax) were modified for ACh and HIST in all groups. On the other hand, the potency for SNP was significantly increased in TR/IR group (8.23 ± 0.06) compared to SD/IR group (7.85 ± 0.04). Contractile responses mediated by a-adrenergic receptor were markedly decreased in IR groups (SD/IR: 6.75 ± 0.06 and TR/IR: 6.62 ± 0.04) compared to SD/SHAM (7.33 ± 0.05). No changes were seen for the U46619 in all groups. In conclusion, the present study shows that exercise training has no protective actions in the local blood vessel where the IR process takes place. © 2006 Elsevier Inc. All rights reserved.en
dc.description.affiliationDepartment of Physical Education Institute of Biosciences University of São Paulo State (UNESP), Rio Claro, SP
dc.description.affiliationDepartment of Pharmacology Faculty of Medical Sciences State University of Campinas (UNICAMP), P.O. Box 6111, 13084-971 Campinas, SP
dc.description.affiliationDepartments of Thoracic Surgery Faculty of Medical Sciences State University of Campinas (UNICAMP), 13084-971 Campinas, SP
dc.description.affiliationUnespDepartment of Physical Education Institute of Biosciences University of São Paulo State (UNESP), Rio Claro, SP
dc.format.extent793-798
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2006.08.037
dc.identifier.citationComparative Biochemistry and Physiology - A Molecular and Integrative Physiology, v. 147, n. 3, p. 793-798, 2007.
dc.identifier.doi10.1016/j.cbpa.2006.08.037
dc.identifier.issn1095-6433
dc.identifier.issn1531-4332
dc.identifier.lattes4472007237545596
dc.identifier.scopus2-s2.0-34248569667
dc.identifier.urihttp://hdl.handle.net/11449/69732
dc.language.isoeng
dc.relation.ispartofComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
dc.relation.ispartofjcr2.258
dc.relation.ispartofsjr0,836
dc.relation.ispartofsjr0,836
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectContractile responses
dc.subjectExercise training
dc.subjectPulmonary artery ring
dc.subjectPulmonary ischemia/reperfusion
dc.subjectRelaxation response
dc.subject15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid
dc.subjectacetylcholine
dc.subjectalpha adrenergic receptor
dc.subjecthistamine
dc.subjectnitroprusside sodium
dc.subjectphenylephrine
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectblood vessel
dc.subjectconcentration response
dc.subjectcontrolled study
dc.subjectdrug mechanism
dc.subjectexercise
dc.subjectischemia
dc.subjectmale
dc.subjectnonhuman
dc.subjectprotection
dc.subjectpulmonary artery
dc.subjectrat
dc.subjectreperfusion
dc.subjectrespiratory system
dc.subjectrunning
dc.subjectsitting
dc.subjecttherapy effect
dc.subjectAnimals
dc.subjectBlood Pressure
dc.subjectBody Weight
dc.subjectDose-Response Relationship, Drug
dc.subjectLung
dc.subjectNitrates
dc.subjectNitrites
dc.subjectPhysical Conditioning, Animal
dc.subjectPulmonary Artery
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReperfusion Injury
dc.subjectVasoconstrictor Agents
dc.subjectVasodilator Agents
dc.subjectAnimalia
dc.subjectRattus
dc.subjectRattus norvegicus
dc.titleInfluence of physical preconditioning on the responsiveness of rat pulmonary artery after pulmonary ischemia/reperfusionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4472007237545596
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt
unesp.departmentEducação Física - IBpt

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Rio Claro - IB - Instituto de Biociências