Structure and antimycobacterial activity of the novel organometallic [Pd(C-bzan)(SCN)(dppp)] compound

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Ferreira, Janaina G. [UNESP]
Stevanato, Alessandra [UNESP]
Santana, Anderson M.
Mauro, Antonio Eduardo [UNESP]
Netto, Adelino Vieira de Godoy [UNESP]
Frem, Regina Célia Galvão [UNESP]
Pavan, Fernando R. [UNESP]
Leite, Clarice Q. F. [UNESP]
Santos, Regina H. A.
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Elsevier B.V.
The organometallic compound [Pd(C-bzan)(SCN)(dppp)] {bzan = N-benzylideneaniline, dppp = 1,3-bis(diphenylphosphino)propane} was synthesized and characterized by elemental analyses, infrared and H-1 and P-31(H-1) NMR spectroscopies. The crystal and molecular structures of the title complex were determined by single-crystal X-ray diffraction techniques. In vitro antimycobacterial evaluation demonstrated that the compound [Pd(C-bzan)(SCN)(dppp)] displayed a MIC of 5.15 mu M, which is superior than those values found for some commonly used anti-TB drugs and other Pd(II) complexes. (C) 2012 Elsevier B.V. All rights reserved.
Organometallic Pd(II) compound, 1,3-bis(Diphenylphosphino)propane, Mycobacterium tuberculosis
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Inorganic Chemistry Communications. Amsterdam: Elsevier B.V., v. 23, p. 63-66, 2012.