INFORMAÇÕES LEGENDAS GRUPOS N X = Somente 1 amostra do grupo apresentou a proteína CONTROLE HIDROFÍLICO 15 DIAS 3 XX = 2 amostras do grupo apresentaram a proteína CONTROLE HIDROFÍLICO 45 DIAS 3 XXX = 3 amostras do grupo apresentaram a proteína ALENDRONATO HIDROFÍLICO 15 DIAS 3 ALENDRONATO HIDROFÍLICO 45 DIAS 3 ALENDRONATO HIDROFÓBICO 45 DIAS 3 ALENDRONATO SEM IMPLANTES 1 OBESO HIDROFÍLICO 15 DIAS 3 OBESO HIDROFÍLICO 45 DIAS 3 OBESO HIDROFÓBICO 15 DIAS 3 OBESO HIDRO FÓBICO 45 DIAS 3 NICOTINA HIDROFÍLICO 3 NICOTINA SEM IMPLANTES 1 DIABETES HIDROFÍLICO 3 DIABETES SEM IMPLANTES 1 TOTAL 36 Obese N= 3 N=3 N=3 N=3 N=3 N=3 Protein ID Description Presence/Group Function CONTROLE HIDROFÍLICO 15D CONTROLE HIDROFÍLICO 45D OBESO HIDROFÓBICO 15D OBESO HIDROFÓBICO 45D OBESO HIDROFÍLICO 15D OBESO HIDROFÍLICO 45D Q3MID4 Carbohydrate kinase-like, isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Shpk PE=1 SV=1 X X P02454 Collagen alpha-1(I) chain OS=Rattus norvegicus OX=10116 GN=Col1a1 PE=1 SV=5 XXX XXX XX XXX XXX XXX Type I collagen is a member of group I collagen (fibrillar forming collagen). Cont_P00761 Trypsin OS=Sus scrofa OX=9823 PE=1 SV=1 XXX XXX XXX XX XXX XXX D3Z9D4 Probable allantoicase OS=Rattus norvegicus OX=10116 GN=Dcdc2c PE=4 SV=2 XX X XX X A0A0G2KAN1 Collagen alpha-2(I) chain OS=Rattus norvegicus OX=10116 GN=NEWGENE_621351 PE=1 SV=1 XXX XXX XXX XXX XXX XXX D3ZHD7 Regulatory factor X, 5 (Influences HLA class II expression) (Predicted) OS=Rattus norvegicus OX=10116 GN=Rfx5 PE=1 SV=1 X X X X X Q1EG90 Kelch-like family member 5 OS=Rattus norvegicus OX=10116 GN=Klhl5 PE=2 SV=1 X X Q63257 Interleukin-4 receptor subunit alpha OS=Rattus norvegicus OX=10116 GN=Il4r PE=2 SV=2 X X X XX XX Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation. Q497B0 Omega-amidase NIT2 OS=Rattus norvegicus OX=10116 GN=Nit2 PE=1 SV=1 XXX X X X X XXX Has omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. P49897 Thyroxine 5-deiodinase OS=Rattus norvegicus OX=10116 GN=Dio3 PE=1 SV=3 X X X XX X Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. Q5BKC9 Ephexin-1 OS=Rattus norvegicus OX=10116 GN=Ngef PE=1 SV=2 XX XX XXX XX XX Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. P24090 Alpha-2-HS-glycoprotein OS=Rattus norvegicus OX=10116 GN=Ahsg PE=1 SV=2 XXX XXX XXX XXX XXX XXX Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in cultured rat hepatoma cells. Cont_P02465 Collagen alpha-2(I) chain OS=Bos taurus OX=9913 GN=COL1A2 PE=1 SV=2 XXX XXX X XX XXX Q761X5 Netrin receptor UNC5C OS=Rattus norvegicus OX=10116 GN=Unc5c PE=1 SV=1 XX X X X Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (By similarity). Also involved in corticospinal tract axon guidance independently of DCC (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:11387206). P97837 Disks large-associated protein 2 OS=Rattus norvegicus OX=10116 GN=Dlgap2 PE=1 SV=3 X X May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. G3V9X6 DNA repair protein RAD50 OS=Rattus norvegicus OX=10116 GN=Rad50 PE=1 SV=1 XX X X X XX X F1LQ87 Voltage-dependent N-type calcium channel subunit alpha OS=Rattus norvegicus OX=10116 GN=Cacna1b PE=1 SV=3 X X Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. G3V6M0 A kinase (PRKA) anchor protein 6 OS=Rattus norvegicus OX=10116 GN=Akap6 PE=1 SV=1 X X X D3ZF03 Apoptosis-inducing factor, mitochondria-associated 3 OS=Rattus norvegicus OX=10116 GN=Aifm3 PE=1 SV=1 X X XX X P62804 Histone H4 OS=Rattus norvegicus OX=10116 GN=H4c2 PE=1 SV=2 XXX XX XX XXX XXX XXX Histone H4 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Osteogenic growth peptide Stimulates osteogenesis and hematopoiesis. A0A0G2JXI9 Histone H2B OS=Rattus norvegicus OX=10116 GN=Hist1h2bo PE=3 SV=1 XX X X XX XXX XX D3ZHL8 G protein-coupled receptor 150 OS=Rattus norvegicus OX=10116 GN=Gpr150 PE=4 SV=1 X X X Q62740 Secreted phosphoprotein 24 OS=Rattus norvegicus OX=10116 GN=Spp2 PE=1 SV=2 XX XX X XXX XXX XX Could coordinate an aspect of bone turnover. P08494 Matrix Gla protein OS=Rattus norvegicus OX=10116 GN=Mgp PE=1 SV=2 XX X X X Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. D3ZE04 Collagen type VII alpha 1 chain OS=Rattus norvegicus OX=10116 GN=Col7a1 PE=4 SV=2 XX XX X XX XX XXX A0A0G2JSV6 Globin c2 OS=Rattus norvegicus OX=10116 GN=Hba-a2 PE=1 SV=1 XX XX XXX XX XXX XXX A0A0G2JSH5 Albumin OS=Rattus norvegicus OX=10116 GN=Alb PE=1 SV=1 XX XX X XX XX D3ZJ08 Histone H3 OS=Rattus norvegicus OX=10116 GN=Hist2h3c2 PE=1 SV=1 XXX XXX XXX XXX XXX XX G3V843 Prothrombin OS=Rattus norvegicus OX=10116 GN=F2 PE=1 SV=1 XXX XXX XXX XXX XX XXX Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. A0JPM6 Bone sialoprotein 2 OS=Rattus norvegicus OX=10116 GN=Ibsp PE=2 SV=1 X XX XX X X XXX Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment. P47853 Biglycan OS=Rattus norvegicus OX=10116 GN=Bgn PE=1 SV=1 XXX XX XX XX XX XX May be involved in collagen fiber assembly. D3ZW07 SAM domain-containing protein OS=Rattus norvegicus OX=10116 PE=4 SV=2 X X X P08721 Osteopontin OS=Rattus norvegicus OX=10116 GN=Spp1 PE=1 SV=2 XXX XX XXX X XXX Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. G3V8H4 E3 ubiquitin-protein ligase CBL-C OS=Rattus norvegicus OX=10116 GN=Cblc PE=1 SV=1 X X Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419', has the highest ubiquitin ligase activity among CBL family proteins. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. A0A0G2JUA5 AHNAK nucleoprotein OS=Rattus norvegicus OX=10116 GN=Ahnak PE=1 SV=1 XX X X X A0A0G2JX30 ATPase family, AAA domain-containing 2B OS=Rattus norvegicus OX=10116 GN=Atad2b PE=1 SV=1 X X X 550 G3V7Y2 Osteomodulin OS=Rattus norvegicus OX=10116 GN=LOC103690116 PE=4 SV=1 XX XX X X X X A0A0G2JSP8 Creatine kinase OS=Rattus norvegicus OX=10116 GN=Ckm PE=1 SV=1 XXX XX XX XX X X G3V8D4 Apolipoprotein C-II OS=Rattus norvegicus OX=10116 GN=Apoc2 PE=1 SV=1 X X X XX XX XXX Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. A0A0G2K2P5 Tight junction protein ZO-1 OS=Rattus norvegicus OX=10116 GN=Tjp1 PE=1 SV=1 X X X X TjpP1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:9707407). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting Cdc42bpb to the leading edge of migrating cells (By similarity). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (By similarity). With Tjp2 and Tjp3, participates in the junctional retention and stability of the transcription factor Dbpa, but is not involved in its shuttling to the nucleus (By similarity). A0A0G2KAJ7 Collagen alpha-1(XII) chain OS=Rattus norvegicus OX=10116 GN=Col12a1 PE=1 SV=1 XXX XXX XXX XXX XXX XX G3V8L3 Lamin A, isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Lmna PE=1 SV=1 XX XX XXX XX XXX XXX A0A0G2K151 Apolipoprotein E OS=Rattus norvegicus OX=10116 GN=Apoe PE=1 SV=1 XXX XXX XX XXX XXX XXX G3V8C3 Vimentin OS=Rattus norvegicus OX=10116 GN=Vim PE=1 SV=1 XX XX XX XX XXX XXX B0BN58 Pseudouridine synthase 3 OS=Rattus norvegicus OX=10116 GN=Pus3 PE=2 SV=1 X X X O88201 C-type lectin domain family 11 member A OS=Rattus norvegicus OX=10116 GN=Clec11a PE=2 SV=1 XXX XX X XX X XX Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone. Cont_P04264 Keratin, type II cytoskeletal 1 OS=Homo sapiens OX=9606 GN=KRT1 PE=1 SV=6 XXX XX XX XXX X XXX F1LMU0 Myosin heavy chain 4 OS=Rattus norvegicus OX=10116 GN=Myh4 PE=1 SV=1 XXX X X XXX XXX X A0A0G2JX64 Tropomyosin 1, alpha, isoform CRA_i OS=Rattus norvegicus OX=10116 GN=Tpm1 PE=1 SV=1 XX X X XX X Q9QZ76 Myoglobin OS=Rattus norvegicus OX=10116 GN=Mb PE=1 SV=3 XX X X X X Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. F1LMW3 ADGRG1 C-terminal fragment OS=Rattus norvegicus OX=10116 GN=Adgrg1 PE=1 SV=1 X X X Q01129 Decorin OS=Rattus norvegicus OX=10116 GN=Dcn PE=1 SV=1 XX X X XX XX XX May affect the rate of fibrils formation (By similarity). May be implicated in the dilatation of the rat cervix P02600 Myosin light chain 1/3, skeletal muscle isoform OS=Rattus norvegicus OX=10116 GN=Myl1 PE=1 SV=2 XX X X X XX X Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function A0A0G2JZY3 RALBP1-associated Eps domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Reps1 PE=1 SV=1 X X X G3V881 Leucine rich repeat neuronal 6A, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Lingo1 PE=1 SV=1 X X X Q3KR94 Vitronectin OS=Rattus norvegicus OX=10116 GN=Vtn PE=1 SV=1 XXX XX XX XXX XXX XXX D3ZAF5 Periostin OS=Rattus norvegicus OX=10116 GN=Postn PE=1 SV=1 XX XXX X XX XXX XX P07150 Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=2 XX XX X XXX XXX X Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (By similarity). Has no effect on unstimulated T-cells. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (By similarity). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions (By similarity). Displays Ca2+-dependent binding to phospholipid membranes (PubMed:3020049). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). Annexin Ac2-26 Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Promotes resolution of inflammation and wound healing. Acts via neutrophil N-formyl peptide receptors to enhance the release of CXCL2. P02091 Hemoglobin subunit beta-1 OS=Rattus norvegicus OX=10116 GN=Hbb PE=1 SV=3 XX XX X XX XX X Involved in oxygen transport from the lung to the various peripheral tissues. F6T0B3 Collagen type XI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col11a2 PE=4 SV=1 XX XX X XX XXX XX P04785 Protein disulfide-isomerase OS=Rattus norvegicus OX=10116 GN=P4hb PE=1 SV=2 XX XX X X XX X This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations and following phosphorylation by FAM20C, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. A0A0G2K1A2 Myeloperoxidase OS=Rattus norvegicus OX=10116 GN=Mpo PE=1 SV=1 XX XX X XX X XX Cont_P68103 Elongation factor 1-alpha 1 OS=Bos taurus OX=9913 GN=EEF1A1 PE=1 SV=1 X XX X X X 1202 Q5XIA8 Growth hormone-inducible transmembrane protein OS=Rattus norvegicus OX=10116 GN=Ghitm PE=2 SV=1 X X Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Functions also as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Required for the mitochondrial tubular network and cristae organization (By similarity). Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the proteome (By similarity). F1LMI6 Sodium/glucose cotransporter 2 OS=Rattus norvegicus OX=10116 GN=Slc5a2 PE=3 SV=1 X X XX X XX Q68FP1 Gelsolin OS=Rattus norvegicus OX=10116 GN=Gsn PE=1 SV=1 XX XX X XX X Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity). F1LWX2 60S ribosomal protein L29 OS=Rattus norvegicus OX=10116 PE=3 SV=1 X X X A0A140TAG3 Zinc finger CCCH domain-containing protein 18 OS=Rattus norvegicus OX=10116 GN=Zc3h18 PE=1 SV=1 X D4A628 DNA-directed DNA polymerase OS=Rattus norvegicus OX=10116 GN=Polq PE=3 SV=1 X D3ZWH2 Junctophilin OS=Rattus norvegicus OX=10116 GN=Jph3 PE=1 SV=1 X Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. P63018 Heat shock cognate 71 kDa protein OS=Rattus norvegicus OX=10116 GN=Hspa8 PE=1 SV=1 XX X Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, chaperone-mediated autophagy, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70. Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Substrate recognition component in chaperone-mediated autophagy (CMA), a selective protein degradation process that mediates degradation of proteins with a -KFERQ motif: HSPA8/HSC70 specifically recognizes and binds cytosolic proteins bearing a -KFERQ motif and promotes their recruitment to the surface of the lysosome where they bind to lysosomal protein LAMP2. KFERQ motif-containing proteins are eventually transported into the lysosomal lumen where they are degraded. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1. Interacts with VGF-derived peptide TLQP-21. A0A0G2K601 Collagen type IV alpha 6 chain OS=Rattus norvegicus OX=10116 GN=Col4a6 PE=4 SV=1 X X X Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. D4A624 Shugoshin 1 OS=Rattus norvegicus OX=10116 GN=Sgo1 PE=3 SV=2 X B2RZD6 NDUFA4, mitochondrial complex-associated OS=Rattus norvegicus OX=10116 GN=Ndufa4 PE=1 SV=1 x X F1LRM7 Collagen alpha-1(II) chain OS=Rattus norvegicus OX=10116 GN=Col2a1 PE=1 SV=1 x xx XX X X D4A548 Armadillo repeat-containing, X-linked 5 OS=Rattus norvegicus OX=10116 GN=Armcx5 PE=4 SV=1 X X Q5RJR9 Collagen-binding protein OS=Rattus norvegicus OX=10116 GN=Serpinh1 PE=1 SV=1 x x XXX XX XXX X P07323 Gamma-enolase OS=Rattus norvegicus OX=10116 GN=Eno2 PE=1 SV=2 X Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival. D3ZBL6 Nucleoporin 160 OS=Rattus norvegicus OX=10116 GN=Nup160 PE=1 SV=3 X X F1M897 Collagen type XXII alpha 1 chain OS=Rattus norvegicus OX=10116 GN=Col22a1 PE=1 SV=3 x X G3V6W8 Bone morphogenetic protein 7 OS=Rattus norvegicus OX=10116 GN=Bmp7 PE=3 SV=1 X X F1LXR9 Lymphoid-restricted membrane protein OS=Rattus norvegicus OX=10116 PE=1 SV=3 X X X Cont_P02453 Collagen alpha-1(I) chain OS=Bos taurus OX=9913 GN=COL1A1 PE=1 SV=3 X X X D3ZH14 Transmembrane and coiled-coil domain family 1 OS=Rattus norvegicus OX=10116 GN=Tmcc1 PE=1 SV=1 X X X X P02770 Albumin OS=Rattus norvegicus OX=10116 GN=Alb PE=1 SV=2 X X X Binds water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (By similarity). Does not prevent iron uptake by the bacterial siderophore aerobactin (By similarity). A0A0G2JTH9 LRRGT00097 OS=Rattus norvegicus OX=10116 GN=LOC499407 PE=4 SV=1 X X X F1LUQ9 Uncharacterized protein OS=Rattus norvegicus OX=10116 PE=4 SV=1 x X X A0A0G2JXR4 Olfactory receptor OS=Rattus norvegicus OX=10116 GN=Olr531 PE=3 SV=1 X P16975 SPARC OS=Rattus norvegicus OX=10116 GN=Sparc PE=1 SV=4 xx xxx X XX XX XX Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity. O55006 Protein RoBo-1 OS=Rattus norvegicus OX=10116 PE=1 SV=1 X May play a novel role in the growth or remodeling of bone. D3ZEJ5 Dual oxidase maturation factor 2 OS=Rattus norvegicus OX=10116 GN=Duoxa2 PE=3 SV=1 x X X A0A0G2JUE3 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus OX=10116 GN=Svep1 PE=4 SV=1 X D4ABC6 RCG36096 OS=Rattus norvegicus OX=10116 GN=Zfp518b PE=4 SV=2 X X X P48675 Desmin OS=Rattus norvegicus OX=10116 GN=Des PE=1 SV=2 x x X X Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin. D3ZMI0 Angiopoietin-like 8 OS=Rattus norvegicus OX=10116 GN=Angptl8 PE=4 SV=2 X XX X F1LY25 Potassium voltage-gated channel subfamily Q member 5 OS=Rattus norvegicus OX=10116 GN=Kcnq5 PE=1 SV=3 X X D4A7X9 Myosin IF OS=Rattus norvegicus OX=10116 GN=Myo1f PE=1 SV=1 X D3ZXG0 Protein phosphatase 1, regulatory subunit 27 OS=Rattus norvegicus OX=10116 GN=Ppp1r27 PE=4 SV=1 X D4A280 Serine/threonine-protein kinase PAK 5 OS=Rattus norvegicus OX=10116 GN=Pak5 PE=1 SV=1 X XX Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions (By similarity). D3Z9E1 Elastin microfibril interfacer 1 OS=Rattus norvegicus OX=10116 GN=Emilin1 PE=1 SV=1 X XX X A0A0G2K6I6 Delta-tubulin OS=Rattus norvegicus OX=10116 GN=Tubd1 PE=3 SV=1 X X Q7M6Z5 Kinesin-like protein KIF27 OS=Rattus norvegicus OX=10116 GN=Kif27 PE=1 SV=1 X XX Plays an essential role in motile ciliogenesis. F1LV07 Dynein, axonemal, heavy chain 9 OS=Rattus norvegicus OX=10116 GN=Dnah9 PE=3 SV=3 X Q06606 Granzyme-like protein 2 OS=Rattus norvegicus OX=10116 GN=Mcpt10 PE=2 SV=1 X X This enzyme is necessary for target cell lysis in cell-mediated immune responses. Q8K5A9 Death domain-containing membrane protein NRADD OS=Rattus norvegicus OX=10116 GN=Nradd PE=1 SV=2 X Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis. Q63190 Emerin OS=Rattus norvegicus OX=10116 GN=Emd PE=1 SV=1 X X X X Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. G3V861 Cytochrome P450, family 26, subfamily A, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp26a1 PE=3 SV=1 X X Q62865 cGMP-inhibited 3',5'-cyclic phosphodiesterase A OS=Rattus norvegicus OX=10116 GN=Pde3a PE=1 SV=1 X X Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. A0A0G2K094 AT-rich interaction domain 4A OS=Rattus norvegicus OX=10116 GN=Arid4a PE=1 SV=1 xxx X F7ENQ2 RCG56764, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Rnf32 PE=4 SV=1 X X P21961 Mast cell carboxypeptidase A (Fragment) OS=Rattus norvegicus OX=10116 GN=Cpa3 PE=1 SV=2 xx x X A0A0G2K677 Spectrin beta chain OS=Rattus norvegicus OX=10116 GN=Sptbn4 PE=1 SV=1 X P98193 Dentin matrix acidic phosphoprotein 1 OS=Rattus norvegicus OX=10116 GN=Dmp1 PE=2 SV=1 X XX X X X X May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity). Q63170 Dynein axonemal heavy chain 7 OS=Rattus norvegicus OX=10116 GN=Dnah7 PE=2 SV=2 X X Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Q6P7A7 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Rattus norvegicus OX=10116 GN=Rpn1 PE=1 SV=1 X X Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc3Man9GlcNAc2 in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. P05197 Elongation factor 2 OS=Rattus norvegicus OX=10116 GN=Eef2 PE=1 SV=4 X Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. A0A0G2JTA4 GTPase, very large interferon-inducible 1 OS=Rattus norvegicus OX=10116 GN=Gvin1 PE=1 SV=1 X X X A0A0G2K2V6 Keratin, type I cytoskeletal 10 OS=Rattus norvegicus OX=10116 GN=Krt10 PE=1 SV=1 X X Q5I0L3 Tyrosine--tRNA ligase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Yars2 PE=2 SV=1 X X Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). D3ZZT9 Collagen type XIV alpha 1 chain OS=Rattus norvegicus OX=10116 GN=Col14a1 PE=1 SV=3 X XX X X Q9QZK5 Serine protease HTRA1 OS=Rattus norvegicus OX=10116 GN=Htra1 PE=2 SV=1 XX X X X X Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets (By similarity). G3V9H8 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Rattus norvegicus OX=10116 GN=Ret PE=1 SV=1 XX X X Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration (By similarity). Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (By similarity). Cont_A5PJ69 SERPINA10 protein OS=Bos taurus OX=9913 GN=SERPINA10 PE=2 SV=1 X D3ZXW4 Glial cells missing homolog 2 (Drosophila) (Predicted) OS=Rattus norvegicus OX=10116 GN=Gcm2 PE=4 SV=1 X Q9QYU4 Ketimine reductase mu-crystallin OS=Rattus norvegicus OX=10116 GN=Crym PE=1 SV=1 X X Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity). E9PSJ3 Kinesin family member 4A OS=Rattus norvegicus OX=10116 GN=Kif4a PE=1 SV=1 X 2952 O54861 Sortilin OS=Rattus norvegicus OX=10116 GN=Sort1 PE=1 SV=3 X X Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin (By similarity). May also mediate transport from the endoplasmic reticulum to the Golgi (PubMed:12771154). P11980 Pyruvate kinase PKM OS=Rattus norvegicus OX=10116 GN=Pkm PE=1 SV=3 X Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival. Isoform M2 Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity. In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase. Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase. Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription. Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (By similarity). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages. May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (By similarity). Isoform M1 Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity. A0A0G2K3Z5 Acyl-CoA-binding domain-containing protein 5 OS=Rattus norvegicus OX=10116 PE=3 SV=1 X X X Q62669 Globin a1 OS=Rattus norvegicus OX=10116 GN=LOC103694855 PE=1 SV=1 X X XXX X XX Q63488 Sodium-dependent phosphate transporter 2 OS=Rattus norvegicus OX=10116 GN=Slc20a2 PE=1 SV=1 X X Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:8041748, PubMed:19073637). Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). F1M8X9 Golgi brefeldin A-resistant guanine nucleotide exchange factor 1 OS=Rattus norvegicus OX=10116 GN=Gbf1 PE=1 SV=2 X A0A096MIV6 Polypeptide N-acetylgalactosaminyltransferase 17 (Fragment) OS=Rattus norvegicus OX=10116 GN=Galnt17 PE=4 SV=1 X X Q05962 ADP/ATP translocase 1 OS=Rattus norvegicus OX=10116 GN=Slc25a4 PE=1 SV=3 X X X ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A4/ANT1 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (By similarity). It is however unclear if SLC25A4/ANT1 constitutes a pore-forming component of mPTP or regulates it (By similarity). Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1 (By similarity). F1LPY6 Phospholipase A2 OS=Rattus norvegicus OX=10116 GN=Pla2g4e PE=4 SV=2 X X D4A7Y1 Aggrecan core protein OS=Rattus norvegicus OX=10116 GN=Acan PE=1 SV=3 X X F7EP77 Centromere protein N OS=Rattus norvegicus OX=10116 GN=Cenpn PE=3 SV=1 X P02262 Histone H2A type 1 OS=Rattus norvegicus OX=10116 PE=1 SV=2 X X X Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. A0A0G2JUX4 Ubiquitin-specific peptidase 47 OS=Rattus norvegicus OX=10116 GN=Usp47 PE=1 SV=1 X X P51886 Lumican OS=Rattus norvegicus OX=10116 GN=Lum PE=1 SV=1 X X XX X XX A0A096MK15 Nebulin OS=Rattus norvegicus OX=10116 GN=Neb PE=1 SV=1 X X X X X A0A0H2UHS7 60S ribosomal protein L18 OS=Rattus norvegicus OX=10116 GN=Rpl18 PE=1 SV=1 X X Cont_P35527 Keratin, type I cytoskeletal 9 OS=Homo sapiens OX=9606 GN=KRT9 PE=1 SV=3 XX XX X X XX Q499V8 Specifically androgen-regulated gene protein OS=Rattus norvegicus OX=10116 GN=Sarg PE=1 SV=2 X X Putative androgen-specific receptor. A0A0G2JXL5 Uncharacterized protein OS=Rattus norvegicus OX=10116 PE=4 SV=1 X X F1LNH3 Collagen type VI alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col6a2 PE=1 SV=2 XX XX X A0A4X0WLY2 Matrix extracellular phosphoglycoprotein OS=Rattus norvegicus OX=10116 GN=Mepe PE=4 SV=1 XX X X X XX D3ZQR6 EMAP-like 6 OS=Rattus norvegicus OX=10116 GN=Eml6 PE=3 SV=3 X XX X May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic P06761 Endoplasmic reticulum chaperone BiP OS=Rattus norvegicus OX=10116 GN=Hspa5 PE=1 SV=1 X XX X X XXX X Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity). M0R660 Glyceraldehyde-3-phosphate dehydrogenase OS=Rattus norvegicus OX=10116 PE=1 SV=1 X X X Cont_P13646 Keratin, type I cytoskeletal 13 OS=Homo sapiens OX=9606 GN=KRT13 PE=1 SV=4 X G3V865 RCG57761 OS=Rattus norvegicus OX=10116 GN=Slc25a28 PE=3 SV=1 X F7F389 Complement component C9 OS=Rattus norvegicus OX=10116 GN=C9 PE=1 SV=1 X XX XXX XX Q5U211 Sorting nexin-3 OS=Rattus norvegicus OX=10116 GN=Snx3 PE=1 SV=1 X X Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons 3647 F1M8J3 Protein-tyrosine-phosphatase OS=Rattus norvegicus OX=10116 GN=Ptprv PE=4 SV=1 X X A0A0H2UHR6 Coagulation factor X OS=Rattus norvegicus OX=10116 GN=F10 PE=1 SV=1 XX XXX XXX XXX XXX XXX G3V6W1 Glutamate receptor OS=Rattus norvegicus OX=10116 GN=Gria4 PE=1 SV=3 X X X Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. G3V939 Keratin 82 OS=Rattus norvegicus OX=10116 GN=Krt82 PE=3 SV=3 X X XX X XX D4A2D3 RCR-type E3 ubiquitin transferase OS=Rattus norvegicus OX=10116 GN=Mycbp2 PE=1 SV=3 X O88767 Parkinson disease protein 7 homolog OS=Rattus norvegicus OX=10116 GN=Park7 PE=1 SV=1 X X X X Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbinols), preventing the formation of advanced glycation endproducts (AGE) that cause irreversible damage. Also functions as a nucleotide deglycase able to repair glycated guanine in the free nucleotide pool (GTP, GDP, GMP, dGTP) and in DNA and RNA. Is thus involved in a major nucleotide repair system named guanine glycation repair (GG repair), dedicated to reversing methylglyoxal and glyoxal damage via nucleotide sanitization and direct nucleic acid repair. Also displays an apparent glyoxalase activity that in fact reflects its deglycase activity. Plays an important role in cell protection against oxidative stress and cell death acting as oxidative stress sensor and redox-sensitive chaperone and protease; functions probably related to its primary function. It is involved in neuroprotective mechanisms like the stabilization of NFE2L2 and PINK1 proteins, male fertility as a positive regulator of androgen signaling pathway as well as cell growth and transformation through, for instance, the modulation of NF-kappa-B signaling pathway. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. Required for correct mitochondrial morphology and function as well as for autophagy of dysfunctional mitochondria. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Regulates astrocyte inflammatory responses, may modulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells (By similarity). In pancreatic islets, involved in the maintenance of mitochondrial reactive oxygen species (ROS) levels and glucose homeostasis in an age- and diet dependent manner. Protects pancreatic beta cells from cell death induced by inflammatory and cytotoxic setting (By similarity). Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Metal-binding protein able to bind copper as well as toxic mercury ions, enhances the cell protection mechanism against induced metal toxicity (By similarity). In macrophages, interacts with the NADPH oxidase subunit NCF1 to direct NADPH oxidase-dependent ROS production, and protects against sepsis (By similarity). P02761 Major urinary protein OS=Rattus norvegicus OX=10116 PE=1 SV=1 X X XX XX Major urinary proteins (Mups) bind and release pheromones. They may also protect pheromones from oxidation. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance. Acts as a kairomone, detected by the prey vomeronasal organ and inducing fear reactions in mice. M0RCW1 Similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27) OS=Rattus norvegicus OX=10116 GN=LOC688321 PE=4 SV=1 X X P20762 Ig gamma-2C chain C region OS=Rattus norvegicus OX=10116 PE=2 SV=1 X X XX X A0A0G2JVB6 Syntaxin-12 OS=Rattus norvegicus OX=10116 GN=Stx12 PE=1 SV=1 X XX X F1LMF4 Protocadherin Fat 3 OS=Rattus norvegicus OX=10116 GN=Fat3 PE=4 SV=3 X X P08733 Myosin regulatory light chain 2, ventricular/cardiac muscle isoform OS=Rattus norvegicus OX=10116 GN=Myl2 PE=1 SV=2 XX X Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (PubMed:15331360). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). D3ZLP2 Ring finger protein 17 OS=Rattus norvegicus OX=10116 GN=Rnf17 PE=1 SV=1 X X X Q80ZA3 Alpha-2 antiplasmin OS=Rattus norvegicus OX=10116 GN=Serpinf1 PE=1 SV=1 XX XX XX XX XXX XX P02564 Myosin-7 OS=Rattus norvegicus OX=10116 GN=Myh7 PE=1 SV=2 X X X Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. F1LVT1 Zinc finger protein 827 OS=Rattus norvegicus OX=10116 GN=Zfp827 PE=4 SV=3 X X X D4A3J0 RCG55159-like OS=Rattus norvegicus OX=10116 GN=LOC100360821 PE=4 SV=3 X D4A7B6 Transmembrane protein 87B OS=Rattus norvegicus OX=10116 GN=Tmem87b PE=1 SV=2 X X Q10758 Keratin, type II cytoskeletal 8 OS=Rattus norvegicus OX=10116 GN=Krt8 PE=1 SV=3 X Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. G3V7Y3 ATP synthase F1 subunit delta OS=Rattus norvegicus OX=10116 GN=Atp5f1d PE=1 SV=1 X X X D3Z9G1 F-box and WD-40 domain protein 17 OS=Rattus norvegicus OX=10116 GN=Fbxw17 PE=4 SV=2 X X P01836 Ig kappa chain C region, A allele OS=Rattus norvegicus OX=10116 PE=1 SV=1 XX XX P01830 Thy-1 membrane glycoprotein OS=Rattus norvegicus OX=10116 GN=Thy1 PE=1 SV=1 X X May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. Cont_Q3T052 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus OX=9913 GN=ITIH4 PE=1 SV=1 X X D3ZXL5 Nuclear cap-binding protein subunit 3 OS=Rattus norvegicus OX=10116 GN=Ncbp3 PE=1 SV=1 X X A0A0H2UHH2 Serum amyloid P-component OS=Rattus norvegicus OX=10116 GN=Apcs PE=1 SV=1 XX X XX X X P04639 Apolipoprotein A-I OS=Rattus norvegicus OX=10116 GN=Apoa1 PE=1 SV=2 X XX X XX X X Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. D3ZEW7 Constitutive NOS OS=Rattus norvegicus OX=10116 GN=Nos1 PE=1 SV=2 X X F1M7P4 Peripherin OS=Rattus norvegicus OX=10116 GN=Prph PE=1 SV=1 X F1M455 Spen family transcriptional repressor OS=Rattus norvegicus OX=10116 GN=Spen PE=1 SV=3 X X X 4383 D4A1D3 Sacsin molecular chaperone OS=Rattus norvegicus OX=10116 GN=Sacs PE=1 SV=2 X D3ZH90 NME/NM23 family member 5 OS=Rattus norvegicus OX=10116 GN=Nme5 PE=3 SV=2 X X A0A0H2UHK1 Complement C1q subcomponent subunit C OS=Rattus norvegicus OX=10116 GN=C1qc PE=1 SV=1 XX X X D3ZKI5 PHD finger protein 3 OS=Rattus norvegicus OX=10116 GN=Phf3 PE=1 SV=1 X X X F7FF45 Nuclear mitotic apparatus protein 1 OS=Rattus norvegicus OX=10116 GN=Numa1 PE=1 SV=2 X X X X F1LWZ8 LEM domain-containing 3 OS=Rattus norvegicus OX=10116 GN=Lemd3 PE=1 SV=2 X X G3V6P7 Myosin, heavy polypeptide 9, non-muscle OS=Rattus norvegicus OX=10116 GN=Myh9 PE=1 SV=1 X X X X X X Cont_P35908 Keratin, type II cytoskeletal 2 epidermal OS=Homo sapiens OX=9606 GN=KRT2 PE=1 SV=2 X X XX X X X D3ZEB1 Coagulation factor VIII OS=Rattus norvegicus OX=10116 GN=F8 PE=3 SV=3 X X P40307 Proteasome subunit beta type-2 OS=Rattus norvegicus OX=10116 GN=Psmb2 PE=1 SV=1 X Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). D3ZUU6 C-type lectin domain family 3, member B OS=Rattus norvegicus OX=10116 GN=Clec3b PE=1 SV=1 XX XX XXX F7FMY6 Protein C, isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Proc PE=1 SV=1 X XX X XX G3V716 Regulator of G-protein-signaling 20 OS=Rattus norvegicus OX=10116 GN=Rgs20 PE=4 SV=1 X X P04466 Myosin regulatory light chain 2, skeletal muscle isoform OS=Rattus norvegicus OX=10116 GN=Mylpf PE=1 SV=2 X X XXX X Myosin regulatory subunit that plays an essential to maintain muscle integrity during early development (By similarity). Plays a role in muscle contraction (By similarity). Q68FR9-2 Isoform 2 of Elongation factor 1-delta OS=Rattus norvegicus OX=10116 GN=Eef1d X Isoform 1 EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome. Isoform 2 Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). A0A0G2K3K2 Actin, cytoplasmic 1 OS=Rattus norvegicus OX=10116 GN=Actb PE=1 SV=1 X X X X G3V667 Integrin subunit alpha 6 OS=Rattus norvegicus OX=10116 GN=Itga6 PE=1 SV=1 X X X D4A3K7 FERM and PDZ domain-containing 4 OS=Rattus norvegicus OX=10116 GN=Frmpd4 PE=4 SV=1 X D4A4X6 ADAMTS-like 2 OS=Rattus norvegicus OX=10116 GN=Adamtsl2 PE=4 SV=1 X X E9PSL7-3 Isoform 3 of Citron rho-interacting kinase OS=Rattus norvegicus OX=10116 GN=Cit X XXX X Plays a role in cytokinesis (By similarity). Required for KIF14 localization to the central spindle and midbody (By similarity). Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1 (By similarity). It probably binds p21 with a tighter specificity in vivo (By similarity). Displays serine/threonine protein kinase activity (By similarity). Plays an important role in the regulation of cytokinesis and the development of the central nervous system (PubMed:24695496). Phosphorylates MYL9/MLC2 (By similarity). Q62715 Neutrophil antibiotic peptide NP-2 OS=Rattus norvegicus OX=10116 GN=Defa PE=1 SV=1 X XX X X X XX Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus. P02767 Transthyretin OS=Rattus norvegicus OX=10116 GN=Ttr PE=1 SV=1 X XX X XXX XX XX Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. A0A0G2JYE0 Ataxin 2-like OS=Rattus norvegicus OX=10116 GN=Atxn2l PE=1 SV=1 XX X D4A1R0 DEAH-box helicase 37 OS=Rattus norvegicus OX=10116 GN=Dhx37 PE=1 SV=1 X X X F1LSG3 Fas-binding factor 1 OS=Rattus norvegicus OX=10116 GN=Fbf1 PE=4 SV=3 X D3ZMH5 TCDD-inducible poly(ADP-ribose) polymerase OS=Rattus norvegicus OX=10116 GN=Tiparp PE=3 SV=1 X E9PTY6 FRY microtubule-binding protein OS=Rattus norvegicus OX=10116 GN=Fry PE=1 SV=3 X X Q7TQ90 Alcohol dehydrogenase 5 OS=Rattus norvegicus OX=10116 GN=Adh4 PE=1 SV=1 X Q62714 Neutrophil antibiotic peptide NP-4 OS=Rattus norvegicus OX=10116 GN=Np4 PE=1 SV=1 X X X XX X XX Host-defense peptide that has antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi (in vitro) (PubMed:2543629). Exhibits activity against E.coli, A.calcoaceticus, S,aureus and C.albicans (PubMed:2543629). Q9QZW8 Dnaj-like protein OS=Rattus norvegicus OX=10116 GN=Samd13 PE=2 SV=1 XX X D4A831 Adhesion G protein-coupled receptor B3 OS=Rattus norvegicus OX=10116 GN=Adgrb3 PE=1 SV=1 X XX G3V9V8 DEAD-box helicase 31 OS=Rattus norvegicus OX=10116 GN=Ddx31 PE=3 SV=1 X XX D3ZUL3 Collagen type VI alpha 1 chain OS=Rattus norvegicus OX=10116 GN=Col6a1 PE=1 SV=1 X XX XX XX XXX XXX M0R5R0 Vitamin K-dependent protein S OS=Rattus norvegicus OX=10116 GN=Pros1 PE=1 SV=1 X XXX XXX XX XX XX D3ZVB7 Mimecan OS=Rattus norvegicus OX=10116 GN=Ogn PE=1 SV=1 X X XX XX XX Q5XIH1 Asporin OS=Rattus norvegicus OX=10116 GN=Aspn PE=1 SV=1 XX XX XX XX XX X M0RBF1 C3-beta-c OS=Rattus norvegicus OX=10116 GN=C3 PE=1 SV=1 X X X X Acts as a chemoattractant for neutrophils in chronic inflammation. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. A0A0G2JVT8 Uncharacterized protein OS=Rattus norvegicus OX=10116 PE=1 SV=1 X X D3ZNQ4 Ubiquitin specific protease 36 (Predicted) OS=Rattus norvegicus OX=10116 GN=Usp36 PE=4 SV=2 X X D3ZIC9 RCG28359 OS=Rattus norvegicus OX=10116 GN=Zc3hav1l PE=4 SV=1 X X X X G3V742 Collagenase 3 OS=Rattus norvegicus OX=10116 GN=Mmp13 PE=3 SV=1 XX X X X X Q9EPF2 Cell surface glycoprotein MUC18 OS=Rattus norvegicus OX=10116 GN=Mcam PE=1 SV=2 X X Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity). Cont_P01267 Thyroglobulin OS=Bos taurus OX=9913 GN=TG PE=1 SV=1 X X P20761 Ig gamma-2B chain C region OS=Rattus norvegicus OX=10116 GN=Igh-1a PE=1 SV=1 X XX X F1LP05 ATP synthase subunit alpha OS=Rattus norvegicus OX=10116 GN=Atp5f1a PE=1 SV=1 XX X XX X XX XX Produces ATP from ADP in the presence of a proton gradient across the membrane. P12346 Serotransferrin OS=Rattus norvegicus OX=10116 GN=Tf PE=1 SV=3 X XX XX XXX XX XX Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. F1LRE5 Oxysterol-binding protein OS=Rattus norvegicus OX=10116 GN=Osbpl9 PE=1 SV=3 X X D3ZHR4 Ankyrin repeat domain 35 OS=Rattus norvegicus OX=10116 GN=Ankrd35 PE=4 SV=2 X D4A8F2 Ras suppressor protein 1 OS=Rattus norvegicus OX=10116 GN=Rsu1 PE=1 SV=3 X X F1M711 Pecanex-like protein OS=Rattus norvegicus OX=10116 PE=3 SV=3 X D4AED1 LOC361719 (Predicted) OS=Rattus norvegicus OX=10116 GN=Spindoc PE=1 SV=2 X X F1LRV9 Myosin heavy chain 4 OS=Rattus norvegicus OX=10116 GN=Myh1 PE=1 SV=2 X X XX XX X Q07936-2 Isoform Long of Annexin A2 OS=Rattus norvegicus OX=10116 GN=Anxa2 X X X X XX Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. P11497 Acetyl-CoA carboxylase 1 OS=Rattus norvegicus OX=10116 GN=Acaca PE=1 SV=1 X X X Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. P16296 Coagulation factor IX OS=Rattus norvegicus OX=10116 GN=F9 PE=2 SV=2 XX XX XX XXX XXX X Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ ions, phospholipids, and factor VIIIa. D3ZKN4 Similar to junction-mediating and regulatory protein (Predicted) OS=Rattus norvegicus OX=10116 GN=Whamm PE=1 SV=1 X E9PU00 Transient receptor potential cation channel, subfamily V, member 3 OS=Rattus norvegicus OX=10116 GN=Trpv3 PE=4 SV=1 X XX X D3ZVK3 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Rattus norvegicus OX=10116 GN=Trmt6 PE=1 SV=1 X X X Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. A0A0H2UHV1 Capping protein, Arp2/3 and myosin-I linker protein 3 OS=Rattus norvegicus OX=10116 GN=Carmil3 PE=3 SV=1 X X A0A0G2JSW4 Myeloid differentiation primary response gene 116, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Ppp1r15a PE=3 SV=1 X X X A0A0G2KAE3 Kelch domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Klhdc1 PE=4 SV=1 X A0A0G2JTS9 F-box protein 42 OS=Rattus norvegicus OX=10116 GN=Fbxo42 PE=4 SV=1 X D3ZNT5 Collagen type IX alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col9a2 PE=4 SV=1 X XX X X Q62910 Synaptojanin-1 OS=Rattus norvegicus OX=10116 GN=Synj1 PE=1 SV=3 X XX X Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (By similarity). Has a role in clathrin-mediated endocytosis (PubMed:9428629). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). G3V8J0 SH3 domain-binding protein 4 OS=Rattus norvegicus OX=10116 GN=Sh3bp4 PE=1 SV=1 X X X X D3ZAI6 5'-nucleotidase domain-containing 3 OS=Rattus norvegicus OX=10116 GN=Nt5dc3 PE=1 SV=2 X X X D4A401 Testis expressed gene 10 (Predicted) OS=Rattus norvegicus OX=10116 GN=Tex10 PE=1 SV=2 X Q5EAJ6 Inhibitor of nuclear factor kappa-B kinase-interacting protein OS=Rattus norvegicus OX=10116 GN=Ikbip PE=2 SV=1 X Target of p53/TP53 with pro-apoptotic function. F1M0K6 60S ribosomal protein L18a OS=Rattus norvegicus OX=10116 PE=3 SV=2 X X Cont_P07744 Keratin, type II cytoskeletal 4 OS=Mus musculus OX=10090 GN=Krt4 PE=1 SV=2 X P12939 Cytochrome P450 2D10 OS=Rattus norvegicus OX=10116 GN=Cyp2d10 PE=1 SV=1 X X X Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. P14925 Peptidylglycine alpha-amidating monooxygenase OS=Rattus norvegicus OX=10116 GN=Pam PE=1 SV=1 X X Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (By similarity). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monooxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxylation (with S stereochemistry) at the alpha-carbon (C-alpha) of the C-terminal glycine of the peptidylglycine substrate (PubMed:10079066). The second step, catalyzed by the peptidylglycine amidoglycolate lyase (PAL) domain, is the zinc-dependent cleavage of the N-C-alpha bond, producing the alpha-amidated peptide and glyoxylate (PubMed:10079066). Similarly, catalyzes the two-step conversion of an N-fatty acylglycine to a primary fatty acid amide and glyoxylate (PubMed:10079066). A0A0G2K6F2 CUB and Sushi multiple domains 2 OS=Rattus norvegicus OX=10116 GN=Csmd2 PE=4 SV=1 X X M0R9N9 Mbt domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Mbtd1 PE=4 SV=2 X X X X X P0C1X9 Leukocyte-associated immunoglobulin-like receptor 1 OS=Rattus norvegicus OX=10116 GN=Lair1 PE=2 SV=1 XX X X Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity). D3ZSY4 Eosinophil peroxidase OS=Rattus norvegicus OX=10116 GN=Epx PE=1 SV=1 X XX X XX D4ABX6 Multimerin 2 OS=Rattus norvegicus OX=10116 GN=Mmrn2 PE=1 SV=1 X X D3ZK14 Tenascin N OS=Rattus norvegicus OX=10116 GN=Tnn PE=3 SV=2 X X X X X D3ZVK7 Histone H2A OS=Rattus norvegicus OX=10116 GN=Hist1h2ak PE=3 SV=1 XX XX XX A0A096P6L8 Fibronectin OS=Rattus norvegicus OX=10116 GN=Fn1 PE=1 SV=2 X XX XX XXX XX XXX Secreted by contracting muscle, induces liver autophagy, a degradative pathway for nutrient mobilization and damage removal, and systemic insulin sensitization via hepatic ITGA5:ITGB1 integrin receptor signaling. D3ZCS4 IQ motif-containing GTPase-activating protein 3 OS=Rattus norvegicus OX=10116 GN=Iqgap3 PE=1 SV=1 XX XX X X D4AE96 Importin 7 OS=Rattus norvegicus OX=10116 GN=Ipo7 PE=1 SV=1 X X P62982 Ubiquitin-40S ribosomal protein S27a OS=Rattus norvegicus OX=10116 GN=Rps27a PE=1 SV=2 X X X Ubiquitin Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Small ribosomal subunit protein eS31 Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. F1LUQ3 Methylcytosine dioxygenase TET OS=Rattus norvegicus OX=10116 GN=Tet1 PE=3 SV=2 X X Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development. D4A365 Zinc finger and BTB domain-containing 40 OS=Rattus norvegicus OX=10116 GN=Zbtb40 PE=4 SV=3 X F1SW39 PC4 and SFRS1 interacting protein 1 OS=Rattus norvegicus OX=10116 GN=Psip1 PE=1 SV=1 X X Q641X2 RNA polymerase-associated protein LEO1 OS=Rattus norvegicus OX=10116 GN=Leo1 PE=1 SV=1 X X Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling (By similarity). A0A0G2KAG1 SUN domain-containing ossification factor OS=Rattus norvegicus OX=10116 GN=Suco PE=1 SV=1 X X D3ZRE3 Casein kinase I isoform alpha OS=Rattus norvegicus OX=10116 GN=Csnk1a1 PE=1 SV=1 X A0A0G2JXT9 Rho guanine nucleotide exchange factor 17 OS=Rattus norvegicus OX=10116 GN=Arhgef17 PE=1 SV=1 X X A0A0G2K972 Tudor domain-containing 15 OS=Rattus norvegicus OX=10116 GN=Tdrd15 PE=4 SV=1 X X X A0A0G2JXC4 Ubiquitin carboxyl-terminal hydrolase OS=Rattus norvegicus OX=10116 GN=LOC689730 PE=3 SV=1 X X A0A0G2JZ75 Plasmalemma vesicle-associated protein OS=Rattus norvegicus OX=10116 GN=Plvap PE=4 SV=1 X X X XX M0R5Y8 60S ribosomal protein L9 OS=Rattus norvegicus OX=10116 PE=3 SV=2 X X X Q3ZAU4 Kazal-type serine peptidase inhibitor domain 1 OS=Rattus norvegicus OX=10116 GN=Kazald1 PE=2 SV=1 X M0R979 Thrombospondin 1 OS=Rattus norvegicus OX=10116 GN=Thbs1 PE=1 SV=2 XX XXX X XX X X D3ZJA3 RCG49355 OS=Rattus norvegicus OX=10116 GN=Spry4 PE=1 SV=1 XX XX X G3V836 Clusterin OS=Rattus norvegicus OX=10116 GN=Clu PE=1 SV=1 X X X P20760 Ig gamma-2A chain C region OS=Rattus norvegicus OX=10116 GN=Igg-2a PE=1 SV=1 X X XX X X G3V710 Delta-like protein OS=Rattus norvegicus OX=10116 GN=Jag1 PE=4 SV=2 X X Putative Notch ligand involved in the mediation of Notch signaling. P22002 Voltage-dependent L-type calcium channel subunit alpha-1C OS=Rattus norvegicus OX=10116 GN=Cacna1c PE=1 SV=1 X X Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (Probable) (PubMed:15140941, PubMed:15170217). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart (By similarity). Required for normal heart development and normal regulation of heart rhythm (By similarity). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (By similarity). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (By similarity). Cont_P13645 Keratin, type I cytoskeletal 10 OS=Homo sapiens OX=9606 GN=KRT10 PE=1 SV=6 X X XX XX Q5I0K7 UDP-N-acetylglucosamine transferase subunit ALG13 homolog OS=Rattus norvegicus OX=10116 GN=Alg13 PE=1 SV=1 XX X X May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway. A0A0G2KB38 Speckle type BTB/POZ protein-like OS=Rattus norvegicus OX=10116 GN=Spopl PE=3 SV=1 X XX Q9QYP1 Low-density lipoprotein receptor-related protein 4 OS=Rattus norvegicus OX=10116 GN=Lrp4 PE=1 SV=2 X X Mediates SOST-dependent inhibition of bone formation (By similarity). Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling (By similarity). Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation P14668 Annexin A5 OS=Rattus norvegicus OX=10116 GN=Anxa5 PE=1 SV=3 X X XX X X This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Q6QI81 60S ribosomal protein L19 OS=Rattus norvegicus OX=10116 GN=Cnbd2 PE=2 SV=1 X X X F1LRQ3 Ring finger protein 180 OS=Rattus norvegicus OX=10116 GN=Rnf180 PE=4 SV=3 X F1LWY9 Homeobox D8 OS=Rattus norvegicus OX=10116 GN=Hoxd8 PE=4 SV=3 XX XX X Q5EIC4 Probable E3 ubiquitin-protein ligase IRF2BPL OS=Rattus norvegicus OX=10116 GN=Irf2bpl PE=1 SV=1 X Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter D3ZN64 Collagen type XXVIII alpha 1 chain OS=Rattus norvegicus OX=10116 GN=Col28a1 PE=4 SV=3 X X X May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. P20909-2 Isoform 2 of Collagen alpha-1(XI) chain OS=Rattus norvegicus OX=10116 GN=Col11a1 X XX XX XX XXX XX Q64305 Pancreas transcription factor 1 subunit alpha OS=Rattus norvegicus OX=10116 GN=Ptf1a PE=1 SV=1 X Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. F6Q5K7 28S ribosomal protein S18-2, mitochondrial OS=Rattus norvegicus OX=10116 GN=Mrps18b PE=1 SV=1 X Q5PQK3 Tripartite motif-containing 42 OS=Rattus norvegicus OX=10116 GN=Trim42 PE=1 SV=1 X X A0A0G2K242 Zinc finger protein 516 OS=Rattus norvegicus OX=10116 GN=Zfp516 PE=4 SV=1 XX X B0BNJ4 ETHE1, persulfide dioxygenase OS=Rattus norvegicus OX=10116 GN=Ethe1 PE=1 SV=1 X X Q1KZI0 Growth hormone d4 OS=Rattus norvegicus OX=10116 GN=Prl2c1 PE=2 SV=1 X X XX X B2RZ77 Dermatopontin OS=Rattus norvegicus OX=10116 GN=Dpt PE=1 SV=1 XX X X D3ZNC9 RING-type E3 ubiquitin transferase OS=Rattus norvegicus OX=10116 GN=March4 PE=4 SV=1 X Q5U349 Ubiquitin carboxyl-terminal hydrolase 2 OS=Rattus norvegicus OX=10116 GN=Usp2 PE=1 SV=1 X Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities (PubMed:12107281). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (By similarity). Has no deubiquitinase activity against p53/TP53 (By similarity). Prevents MDM2-mediated degradation of MDM4 (By similarity). Plays a role in the G1/S cell-cycle progression in normal and cancer cells (By similarity). Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (PubMed:23213472). Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (PubMed:23213472). Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1 (By similarity). Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (PubMed:12107281). Isoform 2 Circadian clock output effector that regulates Ca2+ absorption in the small intestine. Probably functions by regulating protein levels of the membrane scaffold protein NHERF4 in a rhythmic manner, and is therefore likely to control Ca2+ membrane permeability mediated by the Ca2+ channel TRPV6 in the intestine. A0A0G2JVT4 SPATS2-like protein OS=Rattus norvegicus OX=10116 GN=Spats2l PE=3 SV=1 XX D3ZVD1 Polyhomeotic homolog 1 OS=Rattus norvegicus OX=10116 GN=Phc1 PE=4 SV=1 XX A0A0G2K6X6 Non-specific serine/threonine protein kinase OS=Rattus norvegicus OX=10116 GN=Mark2 PE=1 SV=1 X X A0A140UHX6 Spectrin beta chain OS=Rattus norvegicus OX=10116 GN=Sptb PE=1 SV=1 X D3ZEF7 Lymphocyte antigen 9 OS=Rattus norvegicus OX=10116 GN=Ly9 PE=1 SV=2 X X M0R4F8 Dynamin-binding protein OS=Rattus norvegicus OX=10116 GN=Dnmbp PE=1 SV=2 X X Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi (PubMed:14506234). D3ZZQ1 Assembly factor for spindle microtubules OS=Rattus norvegicus OX=10116 GN=Aspm PE=4 SV=2 X D3Z8T6 Uncharacterized protein OS=Rattus norvegicus OX=10116 PE=3 SV=3 X XX A0A0G2KB73 Replication timing regulatory factor 1 OS=Rattus norvegicus OX=10116 GN=Rif1 PE=1 SV=1 X 492 P39948 G1/S-specific cyclin-D1 OS=Rattus norvegicus OX=10116 GN=Ccnd1 PE=2 SV=1 XXX XX Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. P50115 Protein S100-A8 OS=Rattus norvegicus OX=10116 GN=S100a8 PE=1 SV=3 X X S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn2+ which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, ANXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif; S100A8 seems to contribute to S-nitrosylation site selectivity (By similarity). P11517 Hemoglobin subunit beta-2 OS=Rattus norvegicus OX=10116 PE=1 SV=2 X XX X Involved in oxygen transport from the lung to the various peripheral tissues. P05065 Fructose-bisphosphate aldolase A OS=Rattus norvegicus OX=10116 GN=Aldoa PE=1 SV=2 X X Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (By similarity). In addition, may also function as scaffolding protein (By similarity). D3ZVW3 Zinc finger CCCH-type-containing 4 OS=Rattus norvegicus OX=10116 GN=Zc3h4 PE=1 SV=2 X A0A0G2K8U2 Zinc finger MYM-type-containing 6 OS=Rattus norvegicus OX=10116 GN=Zmym6 PE=4 SV=1 X Q5BJA0 Similar to cathepsin R OS=Rattus norvegicus OX=10116 GN=MGC114246 PE=2 SV=1 X B0BN81 40S ribosomal protein S5 OS=Rattus norvegicus OX=10116 GN=Rps5 PE=1 SV=1 X D3ZHD6 RNA-binding motif protein 15B OS=Rattus norvegicus OX=10116 GN=Rbm15b PE=1 SV=2 XX A0A0G2K862 Trichohyalin OS=Rattus norvegicus OX=10116 GN=Tchh PE=4 SV=1 X D3ZQE7 Janus kinase and microtubule-interacting protein 2 OS=Rattus norvegicus OX=10116 GN=Jakmip2 PE=1 SV=3 X D4A1Z7 Similar to RNA polymerase I transcription termination factor 1 (Predicted), isoform CRA_b OS=Rattus norvegicus OX=10116 GN=Ttf1 PE=1 SV=3 X P62738 Actin, aortic smooth muscle OS=Rattus norvegicus OX=10116 GN=Acta2 PE=2 SV=1 X Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. F1LQ00 Collagen type V alpha 2 chain OS=Rattus norvegicus OX=10116 GN=Col5a2 PE=1 SV=3 X X D3ZYT5 Myelin transcription factor 1 OS=Rattus norvegicus OX=10116 GN=Myt1 PE=3 SV=1 X Q8K3M6 ERC protein 2 OS=Rattus norvegicus OX=10116 GN=Erc2 PE=1 SV=1 X XX Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. Q6QI09 ATP synthase F1 subunit gamma OS=Rattus norvegicus OX=10116 GN=Taf3 PE=1 SV=1 X Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha3beta3. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. F1M147 HYLS1, centriolar and ciliogenesis-associated OS=Rattus norvegicus OX=10116 GN=Hyls1 PE=1 SV=2 X Q5XIH7 Prohibitin-2 OS=Rattus norvegicus OX=10116 GN=Phb2 PE=1 SV=1 X X Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus. In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner.Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. In the nucleus, serves as transcriptional co-regulator. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In the plasma membrane, is involved in IGFBP6-induced cell migration (By similarity). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity). M0R9X4 Zinc finger, ZZ-type-containing 3 OS=Rattus norvegicus OX=10116 GN=Zzz3 PE=4 SV=2 X X D3ZQH6 Phospholipase A2 OS=Rattus norvegicus OX=10116 GN=Pla2g4d PE=4 SV=1 X X A0A0G2K586 Adipocyte-type fatty acid-binding protein OS=Rattus norvegicus OX=10116 GN=Fabp4 PE=1 SV=1 X G3V6D3 ATP synthase subunit beta OS=Rattus norvegicus OX=10116 GN=Atp5f1b PE=1 SV=1 XX Produces ATP from ADP in the presence of a proton gradient across the membrane. F1M278 Zinc finger protein 605 OS=Rattus norvegicus OX=10116 GN=Zfp605 PE=4 SV=3 X D4AB50 RCG51408 OS=Rattus norvegicus OX=10116 GN=Arhgap10 PE=1 SV=1 X F1LMV6 Desmoplakin OS=Rattus norvegicus OX=10116 GN=Dsp PE=1 SV=1 X X Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (PubMed:26858265). P62856 40S ribosomal protein S26 OS=Rattus norvegicus OX=10116 GN=Rps26 PE=3 SV=3 X Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. D3Z979 alpha-1,2-Mannosidase OS=Rattus norvegicus OX=10116 GN=Man1c1 PE=1 SV=2 X P62914 60S ribosomal protein L11 OS=Rattus norvegicus OX=10116 GN=Rpl11 PE=1 SV=2 X X Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. Promotes nucleolar location of PML. P19945 60S acidic ribosomal protein P0 OS=Rattus norvegicus OX=10116 GN=Rplp0 PE=1 SV=2 X Ribosomal protein P0 is the functional equivalent of E.coli protein L10. C0JPT7 Filamin A OS=Rattus norvegicus OX=10116 GN=Flna PE=1 SV=1 X F1LNT0 Dihydropyrimidinase-related protein 4 OS=Rattus norvegicus OX=10116 GN=Dpysl4 PE=3 SV=1 X Q4V8F3 Rhomboid-related protein 4 OS=Rattus norvegicus OX=10116 GN=Rhbdd1 PE=2 SV=1 X Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process o