n e u r o c i r u g i a . 2 0 1 6;2 7(3):129–135 NEUROCIRUGÍA R S s R F B a A R A A K T S B P T H H h 1 www.elsev ier .es /neuroc i rugia eview article pontaneous resolution of traumatic acute ubdural haematomas: A systematic review oberto Bezerra Vital ∗, Pedro Tadao Hamamoto Filho, Victor Azevedo de Oliveira, lávio Ramalho Romero, Marco Antônio Zanini otucatu Medical School; UNESP Univ Estadual Paulista; Department of Neurology, Psychology and Psychiatry, Botucatu, SP, Brazil r t i c l e i n f o rticle history: eceived 19 March 2015 ccepted 10 May 2015 vailable online 2 July 2015 eywords: raumatic brain injury ubdural haematoma rain haemorrhage a b s t r a c t Introduction: Traumatic subdural haematomas often require emergency surgical evacuation. Spontaneous resolution of traumatic acute subdural haematomas (TASDH) is under- reported. Two patients are described with spontaneous resolution of TASDH correlating with previous reports. A discussion is presented on the clinical, pathological and radiological features of TASDH. Methods: A review of the literature was performed using PubMed (Medline), Embase, and Cochrane Library for similar cases. Results: A total 21 articles were included, involving 27 cases well detailed of TASDH with spontaneous resolution or neurological and radiological improvement in less than 24 h. Conclusions: There are two main mechanisms for the spontaneous resolution of acute sub- dural haematomas: dilution in subarachnoid space and redistribution of the haematoma in the subdural space. The primary radiological characteristic of these lesions is a hypodense rim on the outer surface of the clot. Spontaneous resolution of TASDH is unusual. Clinical and radiological surveillance is essential for appropriate management of these patients. © 2015 Sociedad Española de Neurocirugía. Published by Elsevier España, S.L.U. All rights reserved. Resolución espontánea de hematoma subdural agudo traumático: una revisión sistemática r e s u m e n alabras clave: raumatismo craneal ematoma subdural Introducción: Los hematomas subdurales agudos traumáticos (HSDAT) requieren tratamiento quirúrgico de urgencia. Muy raras veces se describen casos de resolución espontánea de HSDAT. Describimos 2 casos de resolución espontánea de HSDAT y revisamos la bibliografía n los aspectos clínicos, patológicos y radiológicos de resolución espon- emorragia cerebral pertinente. Se discute tánea de HSDAT. ∗ Corresponding author. E-mail address: roberto vital@hotmail.com (R.B. Vital). ttp://dx.doi.org/10.1016/j.neucir.2015.05.003 130-1473/© 2015 Sociedad Española de Neurocirugía. Published by Elsevier España, S.L.U. All rights reserved. dx.doi.org/10.1016/j.neucir.2015.05.003 http://www.elsevier.es/neurocirugia http://crossmark.crossref.org/dialog/?doi=10.1016/j.neucir.2015.05.003&domain=pdf mailto:roberto_vital@hotmail.com dx.doi.org/10.1016/j.neucir.2015.05.003 130 n e u r o c i r u g i a . 2 0 1 6;2 7(3):129–135 Métodos: Revisamos la literatura en Pubmed (Medline), Embase y Cochrane Library en busca de casos similares. Resultados: Se incluyeron 21 artículos con 27 casos bien detallados de HSDAT con resolución espontánea o mejora clínica y radiológica en 24 h. Conclusiones: Existen 2 mecanismos principales para la resolución espontánea de hematomas subdurales agudos: la dilución en el espacio subaracnoideo y la redistribu- ción del hematoma en el espacio subdural. La principal característica radiológica de estas lesiones es una cerco hipodenso en la superficie exterior del coágulo. La resolución espon- tánea de HSDAT es rara. La vigilancia clínica y radiológica es esencial para el manejo adecuado de estos pacientes. © 2015 Sociedad Española de Neurocirugía. Publicado por Elsevier España, S.L.U. Todos los derechos reservados. Introduction Traumatic acute subdural hematomas (TASDH) present high morbidity and mortality rates and require surgical inter- vention in almost all cases.1,2 Mechanism of trauma and associated brain parenchymal injuries contribute to the sever- ity of this complex condition.3–5 Conservative treatment may be an option in patients whose neurological status is good,4 but rigorous clinical and radiological observation are recommended,5 and for patients with irreversible neurological damage who are in poor clini- cal condition.6 Because the majority of TASDH are promptly surgically drained, the spontaneous mechanisms for its res- olution are possibly underestimated and its natural course is uncertain. We herein present 2 illustrative cases of TASDH with radio- logical or clinical improvement in less than 24 h. All patients had a good clinical outcome. Additionally, we review the liter- ature and discuss the possible mechanisms for spontaneous resolution of TASDH. Methods We performed a literature review in published case reports in English Language, describing TASDH with improvement or total resolution within 24 h. The search strategy was made using Pubmed, MEDLINE and Cochrane Library databases from January 1980 to December 2013. Keywords from the MESH database were Acute Subdural Hematoma, Resolu- tion, Redistribution and Improvement. Full publications were obtained based on the titles or abstracts selected by at least 2 of the reviewers. All retrieved titles and abstracts were reviewed independently by 2 of the investigators (R.B.V. and P.T.H.F.). Full publications were reviewed to select the studies to be included in the review. Manual searching of reference lists of all retrieved articles completed the article searches. The inclusion criteria for reports were: (1) patients pre- senting with TASDH, (2) neurological and or radiological improvement or total resolution of the hematoma within 24 h, (3) cases with documented radiological assessment, (4) conser- vative treatment and (5) papers published in English. All cases with non-traumatic hematomas, like coagulopathy and others etiologies, with incomplete patient data and spinal primary hematomas were excluded. Results Electronic search found 76 articles. Thirty-four were not selected for non-traumatic etiology of the hematoma, or non- cranial topography or different subject. Among the 42 selected articles, twelve were excluded for missing data, three for neu- rological improvement or resolution of the hematoma after 24 h, five for non-English article after full review and one for non-traumatic etiology. Thus we included 21 articles involv- ing 27 cases of acute subdural hematomas with spontaneous resolution or neurological and radiological improvement (Fig. 1). Through the included 27 cases we found 16 (59%) to be male, 14 (52%) of the hematomas on the right side and 12 (44%) due to traffic accidents. The mean age was 36 years, GCS was 9.3 (median 8) and time for neurological or radio- logical improvement was 6.5 h. Complete data are presented on Table 1. Illustrative cases Case 1 This patient was a 21-year-old female who was a victim of a traffic accident, specifically, a motorcycle collision. The patient had a Glasgow Coma Scale (GCS) score of 12, and an initial Computed Tomography (CT) scan disclosed a left fronto-parietal TASDH that was approximately 12 mm at the largest width and a small ipsilateral temporal contusion. She was then referred to our hospital. At the time of arrival (2 h after the trauma) she had GCS score of 14 with isochoric pho- toreactive pupils. A new CT was performed approximately 6 h after the first, and revealed no subdural collection. The following day, the patient had no symptoms or neurological abnormalities and no TASDH was observed on a CT scan. At a six-month follow-up she remained without complaint and GOS (Glasgow Outcome Scale) 5 (Fig. 2). n e u r o c i r u g i a . 2 0 1 6;2 7(3):129–135 131 Table 1 – TASDH with spontaneous improvement in less than 24 h. Author, year Sex, age (yrsa) Trauma mechanism Initial clinical presentation CT location and size Time for improvement (h) Niikawa, 1989 (Case 3)16 F, 24 Traffic Accident GCS 10, lethargic Left FP 6 Niikawa, 1989 (Case 4)16 M, 48 Traffic Accident GCS 9, right dilated pupil Right FP 6 Joki, 1992 (Case 1)26 F, 21 Fall Injury GCS 9 Left FP 8 Joki, 1992 (Case 2)26 M, 23 Fall Injury GCS 14, right hemiparesis Left FP 24 Matsuyama, 199713 M, 18 Sports Head Injury GCS 15, severe headache and nausea Left FTP, 15 mm 3 Cohen, 199818 M, 27 Traffic Accident GCS 7, left dilated pupil Left FTP 12 Tsui, 200017 M, 54 Fall Injury GCS 15, seizures Right FP, >10 mm 6 Berker, 20033 M, 57 Blunt head injury GCS 7, dilated left pupil Left TP 2.5 Bortolotti, 200419 F, 23 Sports Head Injury GCS 15, headache Left FT, >10 mm 12 Sato, 2005 (Case 2)27 M, 88 Traffic Accident GCS 10 Right FTP 3 Sato, 2005 (Case 1)27 F, 92 Fall Injury GCS 7, right pupil dilated and fixed Right FTP 8 Mirzai, 200528 M, 19 Blunt head injury GCS 9 Right FTP 3 Kapsalaki, 2007 (Case 1)15 M, 29 Traffic Accident GCS 8 Left FT, 18 mm 13 Kapsalaki, 2007 (Case 2)15 F, 24 Traffic Accident GCS 7 Right FP 4 Kapsalaki, 2007 (Case 3)15 F, 29 Traffic Accident GCS 8 Right FT, 9 mm 6.5 Kapsalaki, 2007 (Case 4)15 M, 36 Traffic Accident GCS 8 Left FT, 8 mm 6.5 Cosar, 200711 M, 8 months Fall Injury GCS 15, seizures Right FP, <10 mm 9 Wong, 200920 F, 73 Fall Injury GCS 8 Left FTP, 22.4 mm 5.5 Wen, 20091 M, 22 Trunk trauma (no direct hit) GCS 11, LOCb, lethargic, vomiting Left FTP, 4 Lee, 20096 M, 61 Traffic Accident GCS 4, bilateral non-reactive mydriasis Right FTP, 25.9 mm 14 Yadav, 201122 M, 55 Traffic Accident GCS 6 Right FTP 6 Hadjigeorgiou, 201229 M, 64 Fall Injury GCS 15, headache, nauseas Right, PO, 10 mm 8 Balik, 201314 M, 66 Fall Injury GCS 6, LOCb Left FP 16 Park, 201330 F, 7 Traffic Accident GCS 5, left hemiparesis, right dilated pupil Right FTP 2 Liu, 201331 F, 48 Fall Injury GCS 7, vomiting Right FTP 22 Shin, 201332 F, 48 Traffic Accident GCS 6, lethargic Right FTP, 10 mm 1 Towers, 201433 F, 84 Fall Injury GCS 11 Left FTP, 16 mm 12 FP, frontoparietal region; FTP, frontotemporoparietal region; FT, frontotemporal region; PO, parietooccipital. a C T t t d h t w a 5 l a a Years. b LOC: loss of consciousness. ase 2 his patient was a 28-year-old female who suffered a head- o-head collision during sports practice. Immediately after he collision, she had no symptoms. Within a few hours, she eveloped a headache, vomiting, drowsiness, and seizures. At ospital admission, her symptoms were headache and vomi- ing, she remained conscious (GCS score of 15), and her pupils ere isochoric and photoreactive. The initial CT scan showed left fronto-temporo-parietal TASDH with a midline shift of mm. Treatment for the patient consisted of strict surveil- ance in the neurological intensive care unit. A new CT scan fter 20 h showed a marked decrease in hematoma volume nd midline shift. The patient was discharged after two days without symptoms or neurological abnormalities and GOS 5 (Fig. 3). Discussion TASDH are managed surgically in approximately 90-97% of cases.5,7 The surgical treatment aim to treat the primary lesions and prevent secondary injuries, responsible for the poor prognosis of this entity. Since the majority of published series reports those scenarios, the real prevalence of conser- vative cases is underestimated. For instance, a recent case series revealed an incidence around 32% of TASDH with spon- taneous resolution.8 The lack of novelty regarding the subject is probably the reason for this gap of literature. 132 n e u r o c i r u g i a . 2 0 1 Electronic search 76 references found 34 non-selected for different subjects 42 selected with cranial TASDH reports 1 excluded for non-traumatic etiology 12 excluded for missing data 3 excluded for resolution >24hs 5 excluded for non-english full text 21 articles selected with 27 cases Fig. 1 – Flow chart of literature review. the those proposed mechanisms. Dilution of the subdural hematoma within the CSF occurs From our series review, 14 of the 27 patients had GCS of 9 or lower, six of those with dilated pupils, with clearly indications for surgical evacuation.7 The conservative management was opted mostly by the families, specially when came from Asian countries. Fig. 2 – (a) The initial CT scan immediately after the trauma show between the clot and the inner table of the skull. (b) A CT scan p thin layer of CSF where the clot was seen previously. 6;2 7(3):129–135 Conservative treatment may be plausible in select patients.9 Good candidates are patients whose neurological status is favorable (GCS ≥13), who have a hematoma thickness of less than 10 mm, whose hematoma displays a deviation from the midline structures that is less than 10 mm, who have no other severe associated injuries and who have basal cisterns.4,5 From those aspects, the most relevant for decision of surgical cases are the midline shift and clot volume.10 Spontaneous resolution of TASDH is a known but barely described entity, especially within 24 h. However, it can occur, even with large collections.6 Spontaneous resolution of TASDH may be observed in patients with a good neurological sta- tus (mild to moderate TBI, a transient coma lasting less than 12 h, or an absence of brain contusions),11 with collections in which longitudinal extension is greater than the width of the hematoma,1 collections smaller than 30 cc, collections located near the Sylvian fissure, in young patients,12 in the presence of a previous subdural hygroma11 and in cases with cortical atrophy.4 These are all good prognostic factors. We compiled similar cases from the literature. In our report, both patients were young and had good neurological scores because all of the patients were very young, no previous collec- tions would be present. The mechanical causes were a sports injury in one case and a traffic accident in the others. Both patients had conservative treatment for their hematomas, and either spontaneous resolution or a marked decrease in volume was observed within 24 h. Currently none of the patients has any neurological deficits. Two main mechanisms for spontaneous resolution of TASDH have been proposed: cerebrospinal fluid (CSF) dilu- tion and spatial redistribution of the hematoma. Although the terms found in the literature like resolution, redistribution, dissolution and improvement can occasionally be confuse, we believe the resolution of the hematomas itself is a mixture of when there is an adjacent arachnoid injury; thus, the clot is dissolved by the CSF.13 This phenomenon is observed when s a left fronto-parietal TASDH with a hypodense signal erformed after 6 h shows the absence of the TASDH and a n e u r o c i r u g i a . 2 0 1 6;2 7(3):129–135 133 Fig. 3 – (a) The initial CT scan shows a left fronto-temporo-parietal TASDH with a midline shift of 5 mm. The inner hypodense signal suggests the presence of CSF below the clot. (b) The new CT after 20 h demonstrates a great reduction i t s i d ( f c a m s t i r v i r s s c a w i fi n s t c e b 2 m w n the TASDH and the midline shift. here is an increased amount of blood in both cisternal and ubarachnoid space after clot dissolution10,14 or an increase n the volume of a previous subdural effusion.11 Spatial redistribution of the hematoma has been previously escribed to occur through the following processes: swelling an increase in ICP) may force the expulsion of the hematoma rom its initial site,15,16 redistribution may be associated with ortical atrophy17,18 or redistribution may occur through an djacent linear fracture.3,15 The subdural hematoma may still igrate through the posterior fossa14,19,20 or clivus21 into the pinal subdural space. We believe that for most cases, a combination of both of he previously described mechanisms occurs, as is suspected n our cases, a mixture of redistribution and dissolution. More ecently, a piston-like mechanism was proposed, based on ariation in ICP that is secondary to the primary and secondary njuries,22 although this hypothesis is another variation of the edistribution mechanism. A radiological characteristic that suggests the possibility of pontaneous resolution is the presence of a hypo-to-isodense ignal on the external surface of the clot.1,6,8,11,15,17,23 In our ases, a hypodense rim was observed around the hematoma, nd in case 2, this rim was observed on the inner surface, hich differs from previous reports. This hypodense radiolog- cal signal corroborates the CSF dissolution hypothesis. Our aim was to review the literature for similar cases and nd if new concepts about the pathophysiology of the sponta- eous resolution are available and which subgroup of TASDH hould have conservative treatment as an option. The limi- ation of our review is the searching process selected most ase reports and series, and three retrospective cohorts were xcluded9,24,25 due to lack of individual information. It should e reminded that the time for radiological improvement under 4 h is usually recorded when the CT scan is repeated, thus ay not represent the real time for clinical amelioration. Despite conservative treatment is reserved for patients ith GCS higher or equal than 13, we observe that mean GCS of the patient’s presentation was 9.27, from this review. One may argue that spontaneous resolution of TASDH is just an anecdotal observation through several series. It may be inferred conservative treatment as a plausible choice for patients with those typical radiological features, even in comatose patients, provided by serial clinical and radiologi- cal reevaluation. Recent evidences suggests that about 65% of the conservative TASDH have spontaneous resolution within 8 weeks.10 Prospectively cohorts with strict follow up of patients should be the purpose of future investigations on this sub- ject, evaluating them according to patients demographics, the size of TASDH, their evolution, radiological features, clinical or surgical management, ICP measurement if any and final outcome. Furthermore the radiological characteristics foretell likelihood of resolution would need to be evaluated in a larger series including TASDHs that do not resolve, in order to state a predictive value. Conclusions Spontaneous resolution is possible in patients with TASDH. CSF dissolution and spatial redistribution contribute to the resolution of these hematomas. A hypodense signal within the hematoma may be of predictive value in the deci- sion support for non-surgical treatment, even in comatose patients, provided there will be continuous clinical assess- ment and prompt radiological reevaluation as necessary. Prospective cohort series should be done to define specific subgroups of patients for whom conservative treatment is acceptable. Competing interests The authors declare that there are not any financial or non- financial competing interests regarding this research. . 2 0 1 r 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 134 n e u r o c i r u g i a Funding This research was funded by the authors itself. Written informed consent Consent was obtained from the patient for publication of this Case report and any accompanying images. A copy of the writ- ten consent is available for review by the Editor-in-Chief of this journal. Author contributions RBV: draft and designed the manuscript; PTHF: draft and coor- dinated the manuscript; VAO: reviewed the literature for the similar cases; FRR: grammatical and design review. MAZ: final review. All authors read and approved the final manuscript. Acknowledgements None. e f e r e n c e s 1. Wen L, Liu WG, Ma L, Zhan RY, Li G, Yang XF. Spontaneous rapid resolution of acute subdural hematoma after head trauma: is it truly rare? Case report and relevant review of the literature. Ir J Med Sci. 2009;178:367–71. 2. Bullock MR, Chesnut R, Ghajar J, Gordon D, Hartl R, Newell DW, et al. Surgical management of acute epidural hematomas. Neurosurgery. 2006;58 3 Suppl. S7–S15. 3. Berker M, Gulsen S, Ozcan OE. Ultra rapid spontaneous resolution of acute posttraumatic subdural hematomas in patient with temporal linear fracture. Acta Neurochir (Wien). 2003;145:715–7 [discussion 17]. 4. Mathew P, Oluoch-Olunya DL, Condon BR, Bullock R. 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