Lucinda-Silva, Ruth Meri [UNESP]Evangelista, Raul Cesar [UNESP]2014-05-272014-05-272001-12-01Revista de Ciencias Farmaceuticas, v. 22, n. 1, p. 11-28, 2001.0101-3793http://hdl.handle.net/11449/66730Problems related to the systemic administration of drugs, such as biodistribution, difficulty of targeting, necessity of high doses to achieve adequate levels of the drug in specific sites, toxicity, and undesirable side effects have lead to the development of systems able to direct the drug to specific sites in the body. Among the possible organs to the targeting of drugs, the colon can be used for local and systemic therapies. By developing such systems some models have been tested, using pH dependent release, release controlled by enzymatic degradation, time controlled release systems and pressure controlled release systems. This review presents an overview of the colonic release of drugs and the strategies used to achieve such targeting.11-28porColonic releaseDrug controlled release systemsDrug targetingamylasebeta galactosidasebeta glucosidaseeudragitglycosidasemesalazineolsalazinepolygalacturonasesalazosulfapyridinexylan 1,4 beta xylosidasexylan endo 1,3 beta xylosidasechronic inflammationcolon absorptioncontrolled drug releasedrug binding sitedrug delivery systemdrug distributiondrug megadosedrug releasedrug specificitydrug targetingenteritisenzyme degradationhumanpHpressure measurementside effectArtigoAcesso restrito2-s2.0-00355520645361569184579557