Ramalho, Gualter Lisboa [UNESP]Vane, Matheus FachiniLima, Luciana CavalcantiVane, Lucas Fachini [UNESP]Amorim, Rosa Beatriz [UNESP]Domingues, Maria Aparecida [UNESP]de Moraes, José Mariano Soaresde Carvalho, Lídia Raquel [UNESP]Tanaka, Pedro PauloVane, Luiz Antonio [UNESP]2018-12-112018-12-112016-09-01Acta Cirurgica Brasileira, v. 31, n. 9, p. 621-628, 2016.1678-26740102-8650http://hdl.handle.net/11449/173655PURPOSE: To evaluate the effects of dobutamine (DB), noradrenaline (NA), and their combination (NADB), on volume retention in rabbits submitted to hemorrhage. METHODS: Thirty six rabbits were randomly divided into 6 groups: SHAM, Control, Saline, DB, NA, DB+NA. All the animals, except for SHAM, were subjected to hemorrhage of 25% of the calculated blood volume. Control animals were replaced with their own blood. The other groups received NSS 3 times the volume withdrawn. The intravascular retention, hematocrit, diuresis, central venous pressure, mean arterial pressure, NGAL, dry-to-wet lung weight ratio (DTWR) and the lung and kidney histology were analyzed. RESULTS: Replacement with NSS and NA, DB or NA+DB did not produce differences in the intravascular retention. After hemorrhage, the animals presented a significant decrease in the MAP and CVP, which were maintained until volume replacement. Regarding NGAL, dry-to-wet-lung-weight ratio, lung and kidney histology, there were no statistical differences between the groups. CONCLUSION: The use of noradrenaline, dobutamine or their combination did not increase the intravascular retention of volume after normal saline infusion.621-628engCatecholaminesHemorrhagePlasma volumeRabbitsArtigo10.1590/S0102-865020160090000008S0102-86502016000900621Acesso aberto2-s2.0-84992084002S0102-86502016000900621.pdf7802830125342070