Da Graça Sgarbi, Diana BridonDa Silva, Antonio Jorge RibeiroCarlos, Iracilda Zeppone [UNESP]Silva, Célio LopesAngluster, JaymeAlviano, Celuta Sales2014-05-272014-05-271997-12-01Mycopathologia, v. 139, n. 1, p. 9-14, 1997.0301-486Xhttp://hdl.handle.net/11449/65254Ergosterol peroxide, a presumed product of the H2O2-dependent enzymatic oxidation of ergosterol, has been isolated from yeast from yeast forms of the pathogenic fungus Sporothrix schenckii. The substance, which may have a role in fungal virulence, has been characterized mainly using spectroscopic methods (1H and 13C nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formula of C28H44O3, displaying characteristic features of epidioxy sterols and was reverted to ergosterol when submitted to S. schenckii enzymatic extract.9-14engEpidioxy sterolReactive oxygen speciesSporothrix schenckiiantineoplastic agentdrug derivativeergosterolergosterol 5,8 peroxideergosterol-5,8-peroxidechemistryisolation and purificationmetabolismnuclear magnetic resonance spectroscopySporothrixthin layer chromatographyAntineoplastic AgentsChromatography, Thin LayerErgosterolMagnetic Resonance SpectroscopyFungiArtigo10.1023/A:1006803832164WOS:000072341100002Acesso restrito2-s2.0-00314139981730146818754269