Andrade Chagas, Carlos Eduardo [UNESP]Borges, Maria CarolinaMartini, Lgia AraujoRogero, Marcelo Macedo2014-05-202014-05-202012-01-01Nutrients. Basel: Mdpi Ag, v. 4, n. 1, p. 52-67, 2012.2072-6643http://hdl.handle.net/11449/17410The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes.52-67engvitamin DinflammationdiabetesArtigo10.3390/nu4010052WOS:000300718000005Acesso abertoWOS000300718000005.pdf