Sandrim, Valeria [UNESP]Coeli-Lacchini, Fernanda BorchersTanus-Santos, Jose EduardoLacchini, RiccardoCavalli, Ricardo Carvalho2019-10-062019-10-062019-04-03Hypertension in Pregnancy, v. 38, n. 2, p. 73-77, 2019.1525-60651064-1955http://hdl.handle.net/11449/188808Objectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene. Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed. Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GT n polymorphism.73-77engHMOX1 genotypingoxidative stressplasma HO-1plasma sFLT-1polymorphismPreeclampsiaArtigo10.1080/10641955.2019.1582664Acesso aberto2-s2.0-85062514252