Oliveira Souza, D. M. B.Genre, J.Alves Silva, T. G. [UNESP]Soares, C. P. [UNESP]Borges Ferreira Rocha, K.Nunes Oliveira, C.Nunes Jatoba, C. A.Marco de Leon Andrade, J.Moreau, P.Cunha Medeiros, A. daDonadi, E. A.Oliveira Crispim, J. C. de2018-11-262018-11-262016-01-01Scandinavian Journal Of Immunology. Hoboken: Wiley-blackwell, v. 83, n. 1, p. 38-43, 2016.0300-9475http://hdl.handle.net/11449/158630The subversion mechanisms employed by Helicobacter pylori (H.pylori) to escape from immune surveillance and to establish persistent infection are poorly understood. Growing evidence indicates that expression of HLA-G, a non-classical major histocompatibility complex molecule, negatively regulates immune responses in pathological conditions, including infectious diseases. In this context, we aimed to evaluate HLA-G expression in the gastric microenvironment of individuals harbouring H.pylori and to correlate it with histological variables. Fifty-four gastric specimens from patients harbouring H.pylori infection were evaluated by immunohistochemistry using anti-HLA-G monoclonal antibody. As a result, HLA-G expression was detected in 43 of 54 specimens harbouring H.pylori. The presence of HLA-G was significantly associated with milder colonization by H.pylori (P<0.02), milder inflammatory activity (P<0.02) and bacterium histological location in the gastric antrum. This study is the first to explore HLA-G expression in the context of bacterial infection. Whether the biological role of HLA-G during H.pylori infection is beneficial or hazardous for patients remains to be defined.38-43engArtigo10.1111/sji.12385WOS:000366927600006Acesso restrito