Gehring, Patrícia Alves FrancoSantos, Olímpia Maria MartinsPereira, Gislaine RibeiroAraújo, Magali Benjamim deBonfilio, Rudy [UNESP]2014-05-202014-05-202011-01-01Química Nova. Sociedade Brasileira de Química, v. 34, n. 3, p. 455-461, 2011.0100-4042http://hdl.handle.net/11449/7955This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2³ full factorial design was carried out to achieve the best conditions and HCl 0.1 mol L-1 as dissolution medium, basket as apparatus at 100 rpm and collect time at 30 min were considered adequate. The quantification was carried out by spectrophotometry at 251 nm. Both dissolution procedure and analytical method were validated and all parameters were within the acceptable limits. Since there is no official monograph for this pharmaceutical product, this dissolution test could be applied for quality control routine.455-461pordissolution testcinnarizine2³ full factorial designArtigo10.1590/S0100-40422011000300017S0100-40422011000300017WOS:000289857500017Acesso abertoS0100-40422011000300017.pdf