Effects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight men

Nascimento, M. A.Higa, E. M.S.de Mello, M. T.Tufik, S.Oyama, L. M.Santos, R. V.Amaya Farfan, J.Risso, E. M.De Souza, C. T.Pimentel, G. D.Lira, F. S. [UNESP]2018-12-112018-12-112014-01-01e-SPEN Journal, v. 9, n. 3, 2014.2212-8263http://hdl.handle.net/11449/167616Background & aim: Dyslipidemia is involved with in development of cardiovascular diseases and obesity, exercise is recommended as a successful intervention. Dietary l-arginine (l-arg) supplementation may improve in lipid metabolism. However, these combined strategies on lipid profile were not tested yet. This study examines the effects of short term of l-arg supplementation and acute resistance exercise (AREX) on the blood lipid profile and inflammatory proteins in overweight men. Methods: Seven overweight men, 46±5yrs, body weight 93.1±12.0Kg and BMI 31.7±3kg/m2, participated in a randomized, double-blind and crossover study, distributed into exercise groups, based on the supplementation (6g/day of placebo or Arginine for 7 days). Supplementation periods were separated by 7-days of wash-out. The AREX was comprised of eight exercises, with an exercise intensity of 60% 1RM. The glucose, lipid profile (NEFA, triglycerides, HDL cholesterol, LDL cholesterol and total cholesterol) and inflammatory proteins [plasminogen activator inhibitor-1 (PAI-1) and adiponectin] were determined at rest, immediately, after exercise and 1h after exercise sessions. Results: Triglycerides, total cholesterol, and adiponectin levels not showed time-dependent changes under the different conditions. LDL cholesterol and NEFA levels decreased after 1h recovery periods when compared to rest periods only in l-arg supplementation group (P<0.05). PAI-1 was reduced and HDL cholesterol exhibits increases immediately after AREX and 1h recovery periods when compared with rest periods in both groups (P<0.05). Conclusion: These results indicate that l-arg supplementation can potentiate the effects of exercise inducing changes in the LDL cholesterol and NEFA levels. © 2014 European Society for Clinical Nutrition and Metabolism.engArginine supplementationDyslipidemiaOverweightPlasminogen activator inhibitor-1Resistance exerciseEffects of short-term l-arginine supplementation on lipid profile and inflammatory proteins after acute resistance exercise in overweight menArtigo10.1016/j.clnme.2014.02.002Acesso aberto2-s2.0-849014950362-s2.0-84901495036.pdf