Sasaki, HajimeHirai, KimitoMartins, Christine M. [UNESP]Furusho, HisakoBattaglino, RicardoHashimoto, Koshi2018-12-112018-12-112016-04-01Current Pharmaceutical Design, v. 22, n. 15, p. 2204-2215, 2016.1873-42861381-6128http://hdl.handle.net/11449/173076Background: Periapical periodontitis, also known as periapical lesion, is a common dental disease, along with periodontitis (gum disease). Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and its development is regulated by the host immune/inflammatory response. Metabolic disorders, which are largely dependent on life style such as eating habits, have been interpreted as a “metabolically-triggered” low-grade systemic inflammation and may interact with periapical periodontitis by triggering immune modulation. The host immune system is therefore considered the common fundamental mechanism of both disease conditions. Method: We have reviewed >200 articles to discuss the interrelationship between periapical lesions and metabolic disorders including type 2 diabetes mellitus, hypertension, and non-alcoholic fatty liver diseases (NAFLD), and their common pathological background in immunology/osteoimmunology and cytokine biology. Results: An elevated inflammatory state caused by metabolic disorders can impact the clinical outcome of periapical lesions and interfere with wound healing after endodontic treatment. Although additional well-designed clinical studies are needed, periapical lesions appear to affect insulin sensitivity and exacerbate non-alcoholic steatohepatitis. Conclusion: Immune regulatory cytokines produced by various cell types, including immune cells and adipose tissue, play an important role in this interrelationship.2204-2215engCytokinesHypertensionImmunityInflammationMetabolic disordersNAFLDPeriapical lesionType 2 diabetesArtigo10.2174/1381612822666160216145107Acesso restrito2-s2.0-84974658555